Humpath.com - Human pathology

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• hepatocytic ground glass inclusions

  2 December

  Localization
  hepatocytic ground glass inclusions
  thyrocytic ground glass inclusions
  See also
  nuclear anomalies

• jaws

  2 December

  jaw WKP
  Definition : The jaw is any opposable articulated structure at the entrance of the mouth, typically used for grasping and manipulating food. The term jaws is also broadly applied to the whole of the structures constituting the vault of the mouth and serving to open and close it and is part of the body plan of most animals.
  In mammals, the jaws are made up of the mandible (lower jaw) and the maxilla (upper jaw).
  In the ape there is a reinforcement to the lower jaw bone (...)

• mandible

  2 December

  Adj. mandibular WKP
  Definition : The mandible, lower jaw or jawbone is the largest, strongest and lowest bone in the human face. It forms the lower jaw and holds the lower teeth in place. The mandible sits beneath the maxilla. It is the only movable bone of the skull (discounting the ossicles of the middle ear).

• mandibular epidermoid cyst

  2 December

  epidermoid cyst of the mandible PO
  Definition : An epidermoid cyst is a benign cyst usually found on the skin. Bone cysts are very rare and if they appear in bone they usually appear in the distal phalanges of the fingers.
  Localization
  mandibular epidermoid cyst / maxillar epidermoid cyst Epidermoid cysts of the jaws are uncommon
  Differential diagnosis
  dermoid cyst
  keratocystic odontogenic tumor ( formerly odontogenic keratocyst )
  intraosseous orthokeratinized (...)

• osseous epidemoid cyst

  2 December

  intraossesus epidermoid cyst
  Definition : An epidermoid cyst is a benign cyst usually found on the skin. Bone cysts are very rare and if they appear in bone they usually appear in the distal phalanges of the fingers.
  Localization
  mandibular epidermoid cyst / maxillar epidermoid cyst Epidermoid cysts of the jaws are uncommon
  Open references
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010063/

• renal cell tumors

  2 December

  Types
  renal oncocytoma
  renal cell carcinomas
  See also
  renal tumors
  renal anomalies

• TRAF7

  23 November

  Pathology
  adenomatoid tumor of the male and female genital tract is defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. (#29148537#) Free
  Open references
  Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Mod Pathol. 2018 (...)

• TRAFs

  23 November

  WKP
  Definition : TNF receptor associated factors also known as TRAFs are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.
  Currently, seven TRAF proteins have been characterized in mammals: TRAF1 , TRAF2 , TRAF3 , TRAF4 , TRAF5 , TRAF6 and TRAF7.
  Except for TRAF7 , these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling (...)

• ZBTB46

  23 November

  ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations.
  Pathology
  Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. (#29743654#)
  In a study, all examined cases of Langerhans cell histiocytosis and histiocytic sarcoma (...)

• INSM1

  23 November

  WKP
  Definition: Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.
  Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
  Pathology
  Merkel cell carcinoma (MCC) is an extremely aggressive skin cancer that must be distinguished from other basaloid cutaneous (...)

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