Humpath.com - Human pathology

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• lichenoid eruption

  17 September

  lichenoid reaction (or lichenoid lesion ) WKP
  Definition : A lichenoid eruption is a skin disease characterized by damage and infiltration between the epidermis and dermis (" lichenoid infiltration ").
  The term lichenoid reaction (or lichenoid lesion) refers to a lesion of similar or identical histopathologic and clinical appearance to lichen planus (i.e., an area which resembles lichen planus , both to the naked eye and under a microscope).
  Sometimes dental materials or certain (...)

• lichen myxedematosus

  17 September

  Definition : Scleromyxedema or lichen myxedematosus is a rare papular mucinosis of chronic and progressive course and unknown etiology. It is commonly associated with monoclonal gammopathy and may show extracutaneous manifestations, affecting the heart, lung, kidney, and nerves.
  The diagnosis is based on four criteria: generalized papular and sclerodermoid lesions; mucin deposition, fibroblast proliferation, and fibrosis in the histopathology; monoclonal gammopathy; and no thyroid (...)

• sclerozing cutaneous diseases

  17 September

  sclerosing skin diseases
  Definition: Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis , localized scleroderma , and scleredema adultorum.
  These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the (...)

• cutaneous inflammatory anomalies

  13 September

  See also : cutaneous inflammation
  Types
  acute cutaneous inflammation
  chronic cutaneous inflammation granulomatous cutaneous inflammation
  See also
  cutaneous anomalies

• HPV-associated esophageal epidermoid carcinoma

  11 September

  hpv-related esophageal epidermoid carcinoma
  Human papillomavirus (HPV) is a circular, double-stranded DNA virus with established oncogenic potential in the setting of multiple malignancies, most prominently squamous cell carcinoma of the cervix.
  The established role of HPV in squamous cell cancers of other sites, including the anus and the oropharynx, has resulted in a growing literature aiming to assess the biological and clinical roles of HPV tumor infection in a diversity of cancers. (...)

• BRAF-mutated MMR-proficient adenocarcinoma of the proximal colon

  7 September

  BRAF-mutated microsatellite-stable adenocarcinoma of the proximal colon
  BRAF-mutated proximal colon adenocarcinomas with proficient DNA mismatch repair have a dismal prognosis with an aggressive clinical course and often display mucinous differentiation, focal signet ring histology, and other adverse histologic features such as lymphatic and perineural invasion and high tumor budding. (#22314188#)
  Paywall references
  BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal (...)

• MMR-deficient colorectal carcinoma

  7 September

  Mismatch Repair Deficient Colorectal Carcinomas.
  Mismatch repair-deficient tumors frequently show high-grade histologic features, yet the World Health Organization classifies them as low grade to reflect their favorable prognosis compared with mismatch repair-proficient cancers.
  Intestinal-type colorectal adenocarcinomas are graded based on extent of glandular differentiation, although mucinous, signet-ring cell, and solid cancers are, by convention, classified as high grade.
  Paywall (...)

• neoadjuvant-treated pancreatic ductal adenocarcinoma

  7 September

  Paywall references
  Residual Tumor Index: A Prognostically Significant Pathologic Parameter in Neoadjuvant-treated Pancreatic Ductal Adenocarcinoma. Panni RZ, Gonzalez I, Hartley CP, Williams GA, Liu J, Hawkins WG, Chatterjee D. Am J Surg Pathol. 2018 Aug 31. doi:10.1097/PAS.0000000000001144. PMID: #30179901#

• MEIS1-NCOA2-associated renal sarcoma

  6 September

  Some renal sarcomas are characterized by a MEIS1-NCOA2 gene fusion.
  These neoplasms did not have a distinctive immunohistochemical profile, though both labeled for TLE1.
  The morphologic features are distinct from other sarcomas associated with NCOA2 gene fusions, including mesenchymal chondrosarcoma, congenital/infantile spindle cell rhabdomyosarcoma, and soft tissue angiofibroma.
  The aggressive histologic features of these neoplasms indicate malignant potential, thus warranting (...)

• MEIS1

  6 September

  WKP
  Definition : Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.
  Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (’three amino acid loop extension’) family of homeodomain-containing proteins.
  Pathology
  Novel MEIS1-NCOA2 gene fusions define a (...)

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