Humpath.com - Human pathology

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• matrical tumors

  28 September

  Definition : Matrical tumors are a diverse group of neoplasms composed of cells with matrical differentiation.
  Examples
  onychomatricoma
  onychocytic matricoma localized thickening of the nail plate that may display concurrent melanonychia represents a benign acanthoma of onychocytes
  See also
  cutaeneous tumors
  nails

• onychocytic matricoma

  28 September

  Definition : Onychocytic matricoma typically presents as a localized thickening of the nail plate that may display concurrent melanonychia and represents a benign acanthoma of onychocytes.
  see also
  matrical tumors
  Openreferences
  Alors amygdale végétation tumorectomie sein sans

• adrenal Beckwith-Wiedemann syndrome

  27 September

  PO
  Gross description
  Enlarged adrenal glands (up to 16 g) with cerebriform and nodular surface
  Microscopy
  adrenal cytomegaly
  adrenal cortical cells with bizarre, enlarged polyhedral cells with granular eosinophilic cytoplasm and large, hyperchromatic nuclei with pseudoinclusions
  See also
  adrenal diseases
  adrenal anomalies

• acquired adrenal cortical hyperplasia

  27 September

  PO
  Gross anomalies
  nodular variant: at least one nodule 0.5 cm in diameter, often diffusely nodular adrenal cortex which weighs 6+ grams without fat; glands have rounded edges
  Microscopic (histologic) description
  increased thickness of zona reticularis and fasciculata
  cells in fasciculata may appear lipid depleted
  atypical cells with large hyperchromatic nuclei may be present in nodules (“endocrine atypia”)
  small micronodules may be present near central vein, containing (...)

• adrenal enlargment

  27 September

  Definition : markedly enlarged adrenal glands.
  Examples
  adrenal Wolman disease

• adrenal Wolman disease

  27 September

  PO
  Macroscopic anomalies
  adrenal enlargment / markedly enlarged adrenal glands
  Microscopic anomalies
  adrenal necrosis , adrenal fibrosis and adrenal calcification
  zona fasciculata and reticularis cells have vacuolated cytoplasm
  Differential diagnosis
  Niemann-Pick disease adrenal Niemann-Pick disease
  Other storage diseases adrenal storage diseases

• Waterhouse-Friderichsen syndrome

  27 September

  PO
  Gross anomalies
  adrenal glands are enlarged and hemorrhagic
  extensive adrenal cortical necrosis and adrenal medullary necrosis
  Microscopical anomalies
  adrenal hemorrhage
  adrenal necrosis
  adrenal fibrin deposition
  neutrophilic infiltration of medulla and cortex
  zona glomerulosa cells may be spared.
  See also
  adrenal diseases adrenal infectious diseases
  adrenal (...)

• autoimmune adrenal insufficiency

  27 September

  PO
  Synopsis
  no mrophological anomalies
  See also
  polyglandular autoimmune syndromes type I polyglandular autoimmune syndrome type II polyglandular autoimmune syndrome:

• isolated mineralocorticoid deficiency

  27 September

  PO
  Synopsis
  no morphological anomalies

• adrenal tuberculosis

  26 September

  Synopsis
  Rare cause of adrenal insufficiency in US and Western Europe, more common elsewhere
  Due to Mycobacterium tuberculosis
  No symptoms until glandular destruction almost complete
  Gross anomalies
  : adrenal glands are enlarged, yellow-gray-red and replaced by necrotic material
  Microscopical anomalies
  caseous necrosis of cortex and medulla
  Langhans giant cells and lymphocytes
  may have thin rim of intact cortical tissue
  50% have identifiable bacteria with (...)

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