Human pathology

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A. Molecular pathology

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ceramide

Ceramide and sphingolipids Ceramide and lung inflammation Diseases of ceramide metabolism

cholesterol

Cholesterol metabolism

MPRs

MPRs (mannose-6-phosphate receptors) Endosomal targeting by mannose-6-phosphate tag

nucleotides

Nucleotide biosynthesis from folates

PI

pyruvate

RAFs

Example of RAS-RAF-MAPK (ERKs) signaling RAS-RAF-MAPK (ERK) signaling pathway

sphingolipids

Biosynthesis of sphingolipids Biosynthesis of sphingolipids Sphingolipids

25-hydroxycholesterol

Cholesterol metabolism

3-hydroxybutanoic acid

Aβ

APP and lipid-controlled intramembrane proteolysis APP-processing pathways

acetone

acetyl-CoA

HMG-CoA reductase pathway Main metabolic pathways of metabolism AcetylCoA crossroad AcetylCoA and ketone bodies

aconitase

ACTNs

Alpha-actinin and adherens junction

AKT1

PI3K/PTEN/AKT signaling pathway (From Biocarta)

AKTs

PI3K/PTEN/AKT signaling pathway (From Biocarta)

ALK

ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor ALK immunolabelling in myofibroblastic inflammatory tumor t(2;5)(p23;q35) creating NPM1/ALK fusion gene

AMACR

p504s in prostatic prostatic nephrogenic adenoma.

androstenedione

angioneurins

Angioneurins

APP

APP-processing pathways

APP processing pathway

APP processing pathway

ARF-MDM2-P53 signaling pathway

P53 signaling pathway at KEGG

ATM

ATM signaling pathway BRCAs-ATR-ARM pathway

ATP depletion

ATP depletion in cell injury

ATP7B

Pathways of copper metabolism in the hepatocyte

BACE1

APP processing pathway

BAD

BAD and the PI3K/PTEN/AKT signaling pathway (From Biocarta)

BAX

BAZ1B

WSTF (BAZ1B) and the control of gene expression by Vitamin D (...)

BBS4

BBS4 and centrosome (From Nature Review Genetics)

BCL2

BCL2 immunostaining in tonsilla BCL2 immunostaining in adenoid BCL2 immunostaining in nodal follicular hyperplasia

BCL6

BCL6 partners in B-cell lymphoma

BCR/ABL

Inhibition of Cellular Proliferation in CML by Gleevec

biomolecules

Biomolecules in bacterias

BIRCs

BIRCs (IAPs)

BMPR1A

Juvenile polyps in juvenile polyposis

BMPs

SHH/BMPs gradients in neural tube closure SHH/BMPs gradients in neural tube closure

BPAG1

BPAG1 and hemidesmosome

BTGs

BTG family proteins and cell cycle regulation

cadherin-catenin complex

Beta-catenin-cadherin complex

calcium influx

Calcium influx and cell injury

carnitine shuttle

The carnitine shuttle (Wikipedia) Mitochondrial Carnitine Palmitoyltransferase (CPT) System The fatty acid beta-oxydation pathway (Biocarta)

CASP9

CASP9 and the PI3K/PTEN/AKT signaling pathway (From Biocarta)

caspases pathway

Caspases pathway

CASPs

Caspases pathway The caspases pathway

catalase

Function of catalase

catenins/APC pathway

The beta-catenin-APC complex in the Wnt signaling pathway The beta-catenin-APC complex in the Wnt signaling pathway

CCNB1

Cyclin-B1 intercation with PTCH and the SHH pathway

CCNs

Cell cycle regulation by cyclins

CCS

Copper trafficking Copper trafficking

CD1a

Cutaneous Langerhans histiocytosis CD1a+ Cutaneous Langerhans histiocytosis Cutaneous Langerhans histiocytosis

CD3s

CD3 immunostaining of tonsilla

CD68

CD68 immunostaing of the splenic red pulp (labelling of red pulp (...)

CD99

Ewing sarcoma: CD99 positivity Ewing sarcoma: CD99 positivity Ewing sarcoma: CD99 positivity

CDH1

E-cadherin and adherens junction

CDK4

RB/CDK4 pathway Gatekeepers pathways

CDKs

Cell cycle regulation by CDKs

CEA

CEA in microvillous inclusion disease

cell cycle checkpoint kinases

cetone bodies

From acetyl-CoA to cetone bodies

CFTR

CFTR and beta 2 adrenergic receptor (b2AR) pathway

channelopathies

CHEK2

CHEK2 and the BRCAs DNA repair system

cholesteryl oleate

Cholesterol metabolism

chondroitin sulfate

citrate synthase

CLIP

CLIP and antigen presentation

coenzyme A

COL17A1

BPAG2 (COL17A1) and hemidesmosome

CST3

Prion (a), cystatin C (b), transthyretin (TTR) amd amyloid fibril (...)

CTNNA1

Alpha-catenin and adherens junction

CTNNB1

Beta-catenin and adherens junction

CTNND1

Delta-catenin and adherens junction

cystathionine

cystoproteins

Cystoproteins in cilia and centrosome

cytidine

cytochrome-C

cytosine

cytoskeletal proteins

Cytoskeleton and contact proteins

DCX

Proteins involved in abnormal neuronal migration

desmin

Desmin in desmoplastic small round cell tumor Desmin in desmoplastic small round cell tumor

diacylglycerol

Activation of PKC through G protein coupled receptor (From Biocarta)

dihydrofolate

DLL4

DLL4 signaling

DNA double-strand break repair

DOPA

Melanin biosynthesis from DOPA

DSCs

Desmocollins in the desmosome

DSG1

Desmogleins in the desmosome

DSG3

Desmogleins in the desmosome

DSG4

Desmosomal proteins

DSGs

Desmogleins in the desmosome

DSP

Desmoplakin in desmosomes

DTNs

Dystrobrevins and the dystrophin-glycoprotein complex

dyneins

Dynein arms in cilia and basal body

dystroglycan

Dystroglycan

dystrophin

Dystrophin

dystrophin-glycoprotein complex

Dystrophin-glycoprotein complex (DGC)

E2F1

Cell cycle regulation by RB/E2F

EGF

EGF signaling pathways

eicosanoids

Eicosanoids metabolism

electron transport chain

Main metabolic pathways of metabolism

ELKs

ELKs in the RAS-RAF-MAPKs (ERKs) signaling pathway

EMA

EMA in desmoplastic small round cell tumor (DSRCT)

enzymes

Enzyme activity

ERBB2

The NRG1-ERBBs pathway (From Biocarta) HER proteins

ERBB3

The ERBB3-NDF pathway

ERBBs

The NRG1 (NDF)-ERBB3 pathway Activation of HER proteins

estradiol

ETV6

ETV6 partners ETV6 fusion genes (TEL fusion genes)

EWSR1

EWS partners in fusion genes EWSR1 break-apart probe from Vysis

FA complex

FA complex and the BRCA1 pathway

FAD

FADH2

FANCs

The FANCs and the BRCA1-ATM pathway

fatty acids

Main metabolic pathways of metabolism

FGFRs

FGFRs and PTPN11 (Shp-2)

FGFs

FGFs and PTPN11 (Shp-2)

fibronectin

Extracellular matrix-cell interactions

folate

Folate metabolism Cellular functions of folates Folate-Homocysteine cycle

folic acid

Folate metabolism Cellular functions of folic acid

FOXO3A

FOXO3A and DNA damage

FRAP1

PI3K/Akt signaling FRAP1 (mTOR) and the PI3K/PTEN/AKT signaling pathway (From Biocarta) mTOR organization and mTORCs signaling complexes

FSCNs

Fascin in classic Hodgkin disease

fumarate

fusion proteins

Fusion genes and fusion transcripts

FZDs

FZDs in planar cell polarity pathway (PCP pathway)

gamma secretase

APP processing pathway

GLI1

Cubitus interruptus function

GLI2

SHH-PTCH-GLI signaling pathway

GLI3

GLI3 in cerebral development

glutamate

Glutamate and cerebral ammonia detoxification

glutathione reductase

Function of glutathione reductase

GPRs

Activation of PKC through G protein coupled receptor (From Biocarta)

GPXs

Function of glutathione peroxidases

growth factors

Grpwth factors and PI3K/PTEN/AKT signaling pathway

H2O2

H2O2 generation (From Robbins)

HBs

hemosiderin

Pulmonary hemosiderosis (encephalopathy with recurrent aspirations) Pulmonary hemosiderosis (encephalopathy with recurrent aspirations)

HMG-CoA reductase

HMG-CoA reductase pathway

HMG-CoA symthase

HMG-CoA reductase pathway

homocysteine

Folate-homocysteine pathway

homocysteine cycle

The homocysteine cycle

HSP90

HSP90 and the PI3K/PTEN/AKT signaling pathway (From Biocarta)

hyaluronic acid

ICAM1

ICAM1 and granulocytic diapedesis

ICAM2

ICAM2 and granulocytic diapedesis

ICAMs

ICAM1 and ICAM2 and granulocytic diapedesis

IKBKG

NEMO (IKBKG) in TLR2-, TLR3- and TLR4-mediated signaling

inhibitors of the proteasome

Ubiquitin-Proteasome System

ITGA6

ITGA6 and hemidesmosomes

ITGB4

ITGB4 and hemidesmosomes

ITGBs

Beta-integrinas and the PI3K/PTEN/AKT signaling pathway

JAKs

Stat3 Signaling Pathway

JAKs/STATs signaling pathways

Stat3 Signaling Pathway

JNK signaling pathway

JNK and the planar cell polarity pathway

JNKs

JNK and the planar cell polarity pathway

JUP

Plakoglonin (JUP) in desmosomes

keratan sulfate

ketone bodies

Ketone bodies

Ki67

Ki67 in Burkitt lymphoma Ki67 in Burkitt lymphoma

kinesins

Mechanism of kinesin-dependent vesicle transport along a microtubule

KRT7