Humpath.com - Human pathology

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• Progenetix

  2 July

  The Progenetix database provides an overview of copy number abnormalities in human cancer from currently 31915 array and chromosomal Comparative Genomic Hybridization (CGH) experiments.
  Additionally, the website attempts to identify and present all publications (currently 2503 articles), referring to cancer genome profiling experiments.The database & software are developed by the group of Michael Baudis at the University of (...)

• Mitelman Database

  2 July

• TICdb

  2 July

  TICdb is a database of Translocation breakpoints In Cancer. This update contains 1,374 fusion sequences found in human tumors, involving 431 different genes.
  http://www.unav.es/genetica/TICdb/
  For every fusion, TICdb will return the HGNC name of both partner genes and the original reference (either a GenBank or a Pubmed ID), as well as the fusion sequence.
  TICdb team has also developed ONCOFUSE, a bayesian classifier that predicts the oncogenic potential of fusion genes found by (...)

• AGCOH Solid tumors

  2 July

  Solid tumor entries in The Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/
  0 Adrenal cortical carcinoma Angiomatoid Fibrous Histiocytoma Bladder: Squamous cell carcinoma Bladder: Urothelial carcinomas Bone: Adamantinoma 5 Bone: Aneurysmal bone cysts Bone: Angiosarcoma Bone: Chondroblastoma Bone: Chondroma Bone: Chondromyxoid fibroma 10 Bone: Chondrosarcoma Bone: Conventional Osteosarcoma Bone: Dedifferentiated chondrosarcoma Bone: (...)

• dabrafenib

  24 June

  Tafinlar WKP
  Dabrafenib (trade name Tafinlar) is a drug for the treatment of cancers associated with a mutated version of the gene BRAF.
  Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth.
  Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic (...)

• thoracic solitary fibrous tumor

  24 June

  solitary fibrous tumor of the thoracic cavit
  Open references
  A case of dedifferentiated solitary fibrous tumor of the thoracic cavity. Masuda Y, Kurisaki-Arakawa A, Hara K, Arakawa A, Oh S, Suzuki K, Yao T, Saito T. Int J Clin Exp Pathol. 2013 Dec 15;7(1):386-93. eCollection 2014. PMID: #24427361# [Free]

• solitary fibrous tumor

  24 June

  solitary fibrous tumour
  Molecular biology
  NAB2-STAT6 gene fusion Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (#23313952#, #23313954#)
  References
  Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Chmielecki J, Crago AM, Rosenberg M, O’Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M.
  Nat Genet. 2013 Feb;45(2):131-2. doi:10.1038/ng.2522 . PMID: (...)

• NAB2-STAT6

  24 June

  Pathology
  NAB2-STAT6 gene fusion Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (#23313952#, #23313954#)

• NAB2

  24 June

  Pathology
  NAB2-STAT6 gene fusion Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (#23313952#, #23313954#)

• STAT6

  24 June

  Amplification
  STAT6 is amplified in a subset of dedifferentiated liposarcoma. Doyle LA, Tao D, Mariño-Enríquez A. Mod Pathol. 2014 Jan 24. doi:10.1038/modpathol.2013.247 . PMID: #24457460#
  NAB2-STAT6 gene fusion
  Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (#23313952#, #23313954#)
  IHC marker
  STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. (#24625420#)
  References
  STAT6 (...)

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