Humpath.com - Human pathology

Most recent articles

• MMR-deficient colorectal carcinoma

  7 September

  Mismatch Repair Deficient Colorectal Carcinomas.
  Mismatch repair-deficient tumors frequently show high-grade histologic features, yet the World Health Organization classifies them as low grade to reflect their favorable prognosis compared with mismatch repair-proficient cancers.
  Intestinal-type colorectal adenocarcinomas are graded based on extent of glandular differentiation, although mucinous, signet-ring cell, and solid cancers are, by convention, classified as high grade.
  Paywall (...)

• neoadjuvant-treated pancreatic ductal adenocarcinoma

  7 September

  Paywall references
  Residual Tumor Index: A Prognostically Significant Pathologic Parameter in Neoadjuvant-treated Pancreatic Ductal Adenocarcinoma. Panni RZ, Gonzalez I, Hartley CP, Williams GA, Liu J, Hawkins WG, Chatterjee D. Am J Surg Pathol. 2018 Aug 31. doi:10.1097/PAS.0000000000001144. PMID: #30179901#

• MEIS1-NCOA2-associated renal sarcoma

  6 September

  Some renal sarcomas are characterized by a MEIS1-NCOA2 gene fusion.
  These neoplasms did not have a distinctive immunohistochemical profile, though both labeled for TLE1.
  The morphologic features are distinct from other sarcomas associated with NCOA2 gene fusions, including mesenchymal chondrosarcoma, congenital/infantile spindle cell rhabdomyosarcoma, and soft tissue angiofibroma.
  The aggressive histologic features of these neoplasms indicate malignant potential, thus warranting (...)

• MEIS1

  6 September

  WKP
  Definition : Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.
  Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (’three amino acid loop extension’) family of homeodomain-containing proteins.
  Pathology
  Novel MEIS1-NCOA2 gene fusions define a (...)

• MEIS1-NCOA2

  6 September

  Pathology
  Novel MEIS1-NCOA2 gene fusions define a distinct primitive spindle cell sarcoma of the kidney. (#30179902#)

• prostatic urethral polyp

  30 August

  Definition : polyp of prostatic tissue protruding in the urethral lumen.
  Synopsis
  Mostly in adult men
  Usually asymptomatic but may cause hematuria
  Cystoscopically, the lesions appear as discrete small papillary growths that may be solitary or extensive, producing a velvety coating on the mucosa
  Microscopy
  Papillary fronds contain a thin fibrovascular core and are covered by normal prostatic acinar epithelium
  Occasionally, foci of residual urothelium can be seen
  See also (...)

• urethral anomalies

  30 August

  Types
  caruncle
  diverticula
  inverted papilloma
  leiomyoma
  nephrogenic adenoma / mesonephric adenoma
  papilloma
  polypoid urethritis
  prolapse
  prostatic urethral polyp
  See also
  urethra

• glandular atypia

  30 August

  Atypical Glands
  Examples
  Atypical Glands in Prostate Biopsy http://webpathology.com/image.asp?case=22&n=1
  See also
  atypia

• atypia

  30 August

  Examples
  cellular atypia
  epithelial atypia glandular atypia

• focal glandular atypia

  30 August

  Examples
  atypical small acinar proliferation (ASAP)

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