Humpath.com - Human pathology

Most recent articles

• Jacobsen syndrome

  7 January

  WKP
  Definition : Jacobsen syndrome is a rare chromosomal disorder resulting from deletion of genes from chromosome 11 that includes band 11q24.1. It is a congenital disorder.
  Since the deletion takes place on the q arm of chromosome 11, it is also called 11q terminal deletion disorder. The deletion may range from 5 million to 16x NN million deleted DNA base pairs.
  The severity of symptoms depends on the number of deletions; the more deletions there are, the more severe the symptoms (...)

• Enteropathy-like indolent NK cell proliferation in the gallbladder

  6 January

  Natural killer (NK) cell enteropathy is a lymphoproliferative disorder, initially described by Mansoor and colleagues, that presents in the gastrointestinal tract, and is often mistaken for extranodal NK/T-cell lymphoma on first assessment. This population of cells in this process have an NK-cell phenotype (CD3, CD56, CD2, CD7), lacks evidence of Epstein-Barr virus infection, has germline rearrangement of the T-cell receptor, and a very indolent clinical course.
  An indolent (...)

• enteropathy-like indolent NK cell proliferation

  6 January

  NKCE-like
  Natural killer (NK) cell enteropathy is a lymphoproliferative disorder, initially described by Mansoor and colleagues, that presents in the gastrointestinal tract, and is often mistaken for extranodal NK/T-cell lymphoma on first assessment. This population of cells in this process have an NK-cell phenotype (CD3, CD56, CD2, CD7), lacks evidence of Epstein-Barr virus infection, has germline rearrangement of the T-cell receptor, and a very indolent clinical course.
  An indolent (...)

• NK cell enteropathy

  6 January

  NKCE
  Definition : NK-cell enteropathy is a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma.
  Open references
  NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. Mansoor A, Pittaluga S, Beck PL, Wilson WH, Ferry JA, Jaffe ES. Blood. 2011 Feb 3;117(5):1447-52. doi:10.1182/blood-2010-08-302737. PMID: (...)

• gastric adenomas

  31 December 2019

  PO
  Types
  pyloric gland adenoma of the stomach
  gastric intestinal-type adenoma
  foveolar type gastric adenoma
  gastric hyperplastic polyp
  fundic gland polyp
  See also
  other gastric polyps gastric inflammatory fibroid polyp gastric juvenile polyp gastric Peutz-Jeghers polyp

• splenic nodules

  27 December 2019

  splenic nodule
  Examples
  Sclerozing Angiomatoid Nodular Transformation ; SANT of the spleen https://twitter.com/NigarAKhurram/status/1151145348078997504 https://twitter.com/SibaElHussein/status/1209166039742730241
  splenic tumors
  See also
  splenic anomalies

• molluscum pendulum

  21 December 2019

  fibroepithelial polyp PO

• odontogenic cysts and tumors

  18 December 2019

  PO
  Types
  odontogenic cysts
  odontogenic tumors
  Open references
  https://www.nature.com/articles/3880527

• ocular pathology

  17 December 2019

  PO
  By structures
  conjunctiva
  cornea
  eyelid
  globe
  lacrimal gland / lacrimal duct
  lens and vitreous humor
  orbit and optic nerve
  retina
  uvea : iris , choroid , ciliary body
  limbus
  sclera

• CK20

  16 December 2019

  Expression in normal tissues
  Colon, Merkel cells, small intestine (AJSP 2004;28:1352), stomach
  Urothelium (umbrella cells, AJSP 2001;25:1074)
  Uterus
  Expression in benign lesions or tumors
  Bladder intestinal metaplasia (Mod Path 2006;19:1395)
  Fibroepithelioma of Pinkus (Am J Dermatopathol 2007;29:7)
  GI carcinoid (25%)
  Hydatidiform mole (complete-100%, partial-50%, Gynecol Oncol 2002;87:34)
  Renal oncocytoma (dot-like pattern, J Histochem Cytochem 2001;49:919)
  Expression in (...)

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