Humpath.com - Human pathology

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• ACKD-RCC-like cysts

  17 July

  Definition: Acquired cystic disease-associated renal cell carcinoma (ACKD-RCC), originally described by Tickoo and colleagues, is found exclusively in patients with end-stage renal disease.
  Tickoo and colleagues noted: "Many of the tumors (16 of 24 dominant tumors) appeared to arise in a cyst, most often completely filling the cystic space. The cells lining such cysts were morphologically similar to those in the rest of the tumor."
  Atypical cysts lined with vacuolated cells with (...)

• mitotically active cellular fibroma

  13 July

  mitotically active cellular fibroma of the ovary. MACF
  The ovarian cellular fibrous tumor with mitotic figure >4 per 10 high power field without moderate to severe atypia is defined as mitotically active cellular fibroma according to the 2014 World Health Organization classification.
  As this category is new and rare now, we described here a case of MACF and reviewed the literature.
  MACF of the ovary is a newly defined category and few cases have been reported, while prognostic factors (...)

• uterine PEComa

  13 July

  Uterine perivascular epithelioid cell tumors (PEComas)
  Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms that may show overlapping morphology and immunohistochemistry with uterine smooth muscle tumors.
  Paywall references
  Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors. Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Franco Zannoni G, Carlson J, Slavik T, Tornos (...)

• mixed adenoma well-differentiated neuroendocrine tumor

  13 July

  Mixed Adenoma Well-differentiated Neuroendocrine Tumor (MANET) of the Digestive System
  Definition : Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) consisting of adenoma and well-differentiated neuroendocrine tumor (NET) has been recently defined as "MANET."
  Like mixed adenoneuroendocrine carcinomas, a high-grade malignant form of MiNENs with a poorly differentiated neuroendocrine carcinoma component, a common origin for both tumor constituents may be hypothesized.
  MANET is an (...)

• low-grade osteosarcoma

  13 July

  LGOS
  Definition : Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS).
  Cytogenetics
  LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon.
  Molecular biology
  FRS2 is overexpressed and amplified in several cancer types, including prostate cancer. |WKP|
  Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
  The fibroblast (...)

• FRS2

  13 July

  WKP
  Definition: Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
  Pathology
  FRS2 is overexpressed and amplified in several cancer types, including prostate cancer.
  Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS).
  LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon.
  The fibroblast growth factor receptor substrate (...)

• amphicrine carcinoma

  13 July

  Definition: Amphicrine carcinoma is a distinct type of carcinoma characterized by synchronous exocrine and endocrine differentiation within the same tumor cell.
  Such tumors are exceedingly rare and most commonly recognized in the gastrointestinal tract. In the lung, sporadic descriptions of such lesions exist.
  It is a rare variant of carcinomas showing synchronous exocrine and endocrine differentiation.
  Recognition of this type of tumor is important in terms of tumor classification and (...)

• pulmonary amphicrine carcinoma

  13 July

  Definition: Amphicrine carcinoma is a distinct type of carcinoma characterized by synchronous exocrine and endocrine differentiation within the same tumor cell. Such tumors are exceedingly rare and most commonly recognized in the gastrointestinal tract. In the lung, sporadic descriptions of such lesions exist.
  It is a rare variant of pulmonary carcinoma showing synchronous exocrine and endocrine differentiation.
  Recognition of this type of tumor is important in terms of tumor (...)

• dysplastic lipoma

  13 July

  Dysplastic lipoma is a distinctive atypical fatty tumor variant that has p53 overexpression and RB1 gene abnormalities and lacks MDM2 gene amplification by FISH.
  These tumors have a strong male predominance and a notable tendency to involve the subcutaneous tissue of the shoulders, upper back and posterior neck.
  Multifocality is frequent (18.9% of patients with follow-up information), and there is a rare association with retinoblastoma.
  This tumor warrants separation from ordinary lipoma (...)

• splenic diseases

  6 June

  PO
  See also : splenic anomalies

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