Humpath.com - Human pathology

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• VIN3

  11 September

  HSIL / VINIII / vulvar Bowen disease PO
  Definition : vulvar Bowen disease refers to high grade dysplasia of squamous epithelium or vulvar intraepithelial neoplasia grade III and is characterized by full thickness atypia
  Newer terminology is "usual or high grade vulvar intraepithelial neoplasia or VIN III".

• usual differentiated vulvar intraepithelial neoplasia

  11 September

  usual differentiated VIN
  usual differentiated vulvar intraepithelial neoplasia p16+ "usual type" or "classic type", related to human papillomavirus (HPV) infection and affecting relatively young women The usual type includes warty type, basaloid type and mixed (warty and basaloid) type. The usual type is HPV associated - it is positive for p16, negative or has low indices for p53, and MIB-1 is strongly positive above the basal layer. VIN, usual type (including the sub-categories warty (...)

• PAX8+ tumors

  11 September

  PAX8-expressing tumors
  Definition; PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian tract, and renal/upper urinary tracts. PAX8 is a highly sensitive marker for thyroid tumors, renal tumors, Müllerian tumors, and thymic tumors. Importantly, all lung adenocarcinomas, breast and adrenal neoplasms, and the majority of gastrointestinal tumors are negative for PAX8.
  PAX8 expression in thyroid tumors
  thyroid SCC / thyroid squamous cell carcinoma
  PAX8 is an (...)

• familial angiolipomatosis

  4 September

  Familial angiolipomatosis, which is a benign, autosomal-dominant condition that may be regarded as a subtype of familial multiple lipomatosis (FML) or as a distinct entity.
  Management of this condition may include liposuction or surgery to reduce the tumor burden.

• colorectal lipomatosis

  4 September

  PO
  Definition : Development of multiple benign lipomas throughout the colon.

• lipomatosis

  4 September

  PO
  Examples
  lipomatosis of nerve
  colorectal lipomatosis
  Associations
  Associated with obesity , Cushing disease , steroid therapy , protease inhibitors for HIV
  F- fmilial multiple lipomatosis usually autosomal dominant; multiple lipomas of trunk and extremities with relative sparing of the head and shoulders; due to translocation involving high-mobility-group protein isoform I-C on chromosome 12 and the lipoma preferred partner gene on chromosome 3 (An Bras Dermatol (...)

• conjunctival tumors

  2 September

  Examples
  conjunctival papilloma
  conjunctival melanoma
  conjunctival squamous cell carcinoma

• cunjonctiva

  2 September

  ocular cunjonctiva WKP
  Pathology
  cunjonctival tumors

• ADRB1

  2 September

  Pathology
  A mutation in ADRB1 leads to natural short sleep trait in humans
  Mice engineered with same mutation have similar short sleep behavior as humans
  Activity of dorsal pons ADRB1+ neurons associates with REM sleep and wakefulness
  Mutation increases the population activity of dorsal pons ADRB1+ neurons
  References
  A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. 2019 (...)

• digestive granulomas

  30 August

  Examples
  digestive food granuloma pulse granuloma
  digestive epithelioid and giant cell granuloma

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