The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. They are biosynthesized partly through the phenylpropanoid pathway and the mevalonate pathway, which is biosynthesized by a coupling of dimethylallyl pyrophosphate (DMAPP) and 7-hydroxycoumarin (umbelliferone).
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Bergamot is also a source of bergamottin which, along with the chemically related compound 6’,7’-dihydroxybergamottin, is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.
In the past, psoralen extracted from bergamot oil has been used in tanning accelerators and sunscreens. These substances were known to be photocarcinogenic since 1959, but they were only banned from (...)
Psoralen (also called psoralene) is the parent compound in a family of natural products known as furocoumarins. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone.
Psoralen occurs naturally in the seeds of Psoralea corylifolia, as well as in the common fig, celery, parsley and West Indian satinwood.
It is widely used in PUVA (= psoralen + UVA) treatment for psoriasis, eczema, vitiligo, and cutaneous (...)
Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity.
Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays.
Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary (...)
Role of p38MAPK and oxidative stress in copper-induced senescence.
Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O. Age (Dordr). 2013 Dec;35(6):2255-71. doi:10.1007/s11357-013-9521-3 . PMID: #23576095#
Two clinicopathological variants are recognized: the oestrogen-related (type I, endometrioid carcinoma) and the non-oestrogen-related (type II, non-endometrioid carcinoma).
Whereas type I shows microsatellite instability and mutations in PTEN, PIK3CA, K-RAS and CTNNB1 (beta-catenin), type II exhibits TP53 mutations and chromosomal instability.
Recent investigations regarding the role of non-coding RNA have provided important information regarding tumour progression.
In western countries, (...)
HPC:339 : Kikuchi adenitis (necrotizing histiocytic lymphadenitis)
JRC:991 : Kikuchi’s lymphadenitis in a 27 y/o female.
JRC:15279 : Kikuchi’s lymphadenitis in a 27 y/o female.
necrotizing adenitis necrotizing histiocytic adenitis necrotizing Kikuchi adenitis
TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models.
TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis. Khatamianfar V, Valiyeva F, Rennie PS, Lu WY, Yang BB, Bauman GS, Moussa M, Xuan JW. BMJ Open. 2012 Oct 8;2(5). pii: e001410. doi: 10.1136/bmjopen-2012-001410. PMID: #23048060# (...)
balanitis Zoon balanitis lichen sclerosus et atrophicus (balanitis xerotica obliterans) pseudoepitheliomatous keratotic micaceous balanitis
squamous hyperplasia of the penis
penile intraepithelial neoplasia Bowen disease erythroplasia of Queyrat Bowenoid papulosis
squamous cell carcinoma of the penis usual type of squamous cell carcinoma of the penis basaloid squamous cell carcinoma of the penis penile warty squamous cell carcinoma of the penis (...)