Humpath.com - Human pathology

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• perivascular cell tumors

  29 August

  Types
  glomus tumor / glomic tumor
  hemangiopericytoma / solitary fibrous tumor
  perivascular epithelioid cell tumor (PEComa / PEComas )
  See also
  tumors vascular tumors

• prostatic atypical adenomatous hyperplasia

  29 August

  prostatic adenosis PO
  Definition: A microscopic proliferation of small glands with minimal atypia; may be mistaken for low grade adenocarcinoma. It is sound almost exclusively in transition zone (2% of TURPs, < 1% of core biopsies).
  Microscopy
  The glands are variable in size and show round, oval, or irregular lumina. The cytoplasm is pale in contrast to the amphophilic cytoplasm usually seen in cancer.
  The nuclei are not enlarged appreciably and prominent nucleoli are not (...)

• PIN-like carcinoma

  29 August

  Definition: Prostatic intraepithelial neoplasia like (PIN-like ductal) carcinoma are rare tumors characterized by crowded, often cystically dilated glands architecturally resembling high-grade prostatic intraepithelial neoplasia, lined by malignant pseudostratified columnar epithelium.
  The largest prior series studied 9 radical prostatectomies (RPs) and suggested a behavior similar to Gleason score 6.
  Paywall references
  PIN-like (Ductal) Adenocarcinoma of the Prostate. Paulk A, (...)

• pancreatic mucoepidermoid carcinoma

  29 August

  "Mucoepidermoid carcinoma (MEC)" has been accepted as a synonym for pancreatic adenosquamous carcinoma (ASC). Pancreatic ASC can show salivary gland-type MEC-like morphology.
  Pan-MEC is histologically and biologically high-grade and unrelated to CRTC1/3-MAML2 fusion gene, unlike Sal-MEC which is related to CRTC1/3-MAML2 fusion gene. Pan-MEC is not a pancreatic counterpart of CRTC1/3-MAML2 fusion gene-related Sal-MEC. (#30138216#)
  Paywall references
  "Pancreatic Mucoepidermoid Carcinoma" (...)

• diffuse intrapulmonary malignant mesothelioma.

  28 August

  Paywall references
  Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma. Larsen BT, Smith ML, Roden AC, Sukov WR, Hornychová H, Thirumala S, Colby TV, Tazelaar HD. Am J Surg Pathol. 2018 Aug 22. doi:10.1097/PAS.0000000000001143. PMID: #30138217#

• mesonephric carcinoma of the female genital tract

  28 August

  Mesonephric carcinomas of the gynecologic tract are neoplasms that are often under-recognized due to their varied morphologic appearances.
  IHC
  GATA3 and TTF1 have been reported to be useful immunohistochemical markers for distinguishing mesonephric carcinomas from its morphologic mimics.
  In summary, GATA3 was the best overall marker for mesonephric and mesonephric-like carcinomas, but cannot be used to distinguish mesonephric carcinosarcomas from Müllerian carcinosarcomas.
  The inverse (...)

• tumors of the female reproductive system

  28 August

  WHO
  http://drzafariqbal.com/wp-content/uploads/2017/07/WHO-Female.pdf

• MMR-associated upper tract urothelial carcinoma

  28 August

  Lynch syndrome-associated upper tract urothelial carcinoma
  Predisposition
  Lynch syndrome
  Lynch syndrome (LS) is defined by germline mutations in DNA mismatch repair (MMR) genes, and affected patients are at high risk for multiple cancers.
  Reflexive testing for MMR protein loss by immunohistochemistry (IHC) is currently only recommended for colorectal and endometrial cancers, although upper tract urothelial carcinoma (UTUC) is the third-most common malignancy in patients with LS.
  A (...)

• upper tract urothelial carcinoma

  28 August

  Sublocalization
  upper tract urothelial carcinoma
  pelvic urothelial carcinoma
  Predisposition
  Lynch syndrome
  Lynch syndrome (LS) is defined by germline mutations in DNA mismatch repair (MMR) genes, and affected patients are at high risk for multiple cancers.
  Reflexive testing for MMR protein loss by immunohistochemistry (IHC) is currently only recommended for colorectal and endometrial cancers, although upper tract urothelial carcinoma (UTUC) is the third-most common malignancy in (...)

• vascular tumors of the female genital tract

  27 August

  Vascular Tumours of the Female Genital System
  Paywall references
  http://www.jcdr.net/articles/PDF/1594/3219.pdf
  https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1525-1438.2006.00523.x

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