Integrated genomic characterization of papillary thyroid carcinoma.
Cancer Genome Atlas Research Network.
Cell. 2014 Oct 23;159(3):676-90. doi: 10.1016/j.cell.2014.09.050.
humpath.com supports the 2015 edition of the European Symposium of Biopathology, June 2015 in Paris, France.
Most recent articles
The genomic landscape of childhood and adolescent melanoma.
Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A.
J Invest Dermatol. 2015 Mar;135(3):816-23. (...)
The Molecular Taxonomy of Primary Prostate Cancer.
Cancer Genome Atlas Research Network. Electronic address: email@example.com; Cancer Genome Atlas Research Network.
Cell. 2015 Nov 5;163(4):1011-25. doi: 10.1016/j.cell.2015.10.025.
focal/nodular solid cell nest of the thyroid gland medullary thyroid microcarcinoma focal fibrosing thyroiditis papillary microcarcinoma
diffuse Hashimoto thyroiditis other thyroiditis
focal fibrosing thyroiditis (FFT)
stellate thyroid scar with entrapped follicles within fibrosis
At junction between normal and pathological areas, the inflammatory fibrosis can contain dystrophic follicles, without typical papillary nuclear features.
Chromosomal comparative genomic hybridization (CGH)
low prevalence of aberrations
majority of tumors showing no evidence of chromosomal instability
gains: chromosomes 1, 5, 7, 11, 15, 17, and 22
losses: chromosomes 4, 18, and 19
TP73 (1p36 amplification)
SNRPN (15q12 amplification)
PDGFB (22q13 amplification)
Oncogenic activation of BRAF (35% to 69%), RAS (10%), or RET (5% to 30%) is common in PTC, and the mutations correlate with tumor (...)
Definition: A cyst of Montgomery is a benign breast mass, usually found in adolescent girls. Typically, it resolves spontaneously by itself.
The periareolar glands of Montgomery in the breast are also called Montgomery tubercles or Morgagni tubercles. These periareolar glands are small, papular tissue projections at the edge of the areola (nipple).
Obstruction of the Montgomery tubercles may result in an acute inflammation, a clear or light brownish fluid may drain out of the areola (...)
breast atrophy WP
mammary lesions; mammary tissular anomalies
mammary cellular infiltration
By Anomalies (lesions)