Humpath.com - Human pathology

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• anaphasis

  11 November

  WKP
  Final steps of mitosis
  The final stages of mitosis begin in anaphase, when the mitotic spindle segregates the duplicated chromosomes. Mitotic exit is then completed by disassembly of the spindle and packaging of chromosomes into daughter nuclei.
  The successful completion of mitosis requires that these events occur in a strict order. Two main mechanisms govern progression through late mitosis: dephosphorylation of cyclin-dependent kinase (Cdk) substrates and destruction of the (...)

• endometrial simple atrophy

  11 November

  See also
  endometrial atrophy

• endometrial stroma

  11 November

  See also
  endometrium endometrial epithelium

• endometrial epithelium

  11 November

  Appearance
  cuboidal endometrial epithelium
  columnar endometrial epithelium
  Localization
  endometrial surface epithelium
  endometrial glands / endometrial glandular epithelium
  See also
  endometrium endometrial stroma

• genetic recombination

  11 November

  WKP
  Genetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those found in either parent.
  In eukaryotes, genetic recombination during meiosis can lead to a novel set of genetic information that can be passed on from the parents to the offspring. Most recombination is naturally (...)

• endometrial anomalies

  11 November

  Examples
  endometrial atrophy
  endometrial hyperplasia
  endometrial dysplasia
  endometrial inflammation
  endometrial polyp
  endometrial tumors
  See also
  endometrium

• ALK-rearranged histiocytosis

  11 November

  ALK-positive histiocytosis
  ALK-positive histiocytosis is a systemic histiocytic proliferation of early infancy with hepatosplenomegaly and dramatic hematological disturbances.
  The clinicopathological spectrum of ALK-positive histiocytosis is broader than originally described, and this entity is characterized by frequent presence of KIF5B-ALK gene fusion.
  It has been recommended that every unusual histiocytic proliferative disorder, especially disseminated lesions, be tested for ALK (...)

• test MindMeister

  10 November

  Votre navigateur ne peut pas afficher les images. Veuillez visiter Tube digestif sur MindMeister.Tube digestif par Open Maps

• mutational signatures

  10 November

  WKP
  Examples : ultraviolet mutational signature
  Definition : Mutational signatures are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity, exogenous and endogenous genotoxins exposures, defective DNA repair pathways and DNA enzymatic editing.
  Deciphering mutational signatures in cancer provides insight into the biological mechanisms involved in carcinogenesis and normal somatic mutagenesis.
  Mutational signatures (...)

• STK11-mutated tumors

  10 November

  Pathology
  STK11 somatic mutations in STK11-mutated tumors (#10079245#): STK11-mutated pulmonary adenocarcinoma (#25695224#, #23995788#, #22460425#, #21191700#, #12097271#, #10079245#) STK11-mutated cervical adenocarcinoma (#10079245#)
  See also
  STKs / STK11
  tumors mutated genes in tumors gene-mutated tumors

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