Humpath.com - Human pathology

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• respiratory epithelial adenomatoid hamartoma

  14 October

  Respiratory epithelial adenomatoid hamartoma (REAH)
  Definition: Respiratory epithelial adenomatoid hamartoma (REAH) is regarded as a rare tumor of the nasal cavity. The mechanisms driving the development of REAH are unknown, and its nature as a benign tumor, hamartoma, or reactive inflammatory process is still open to discussion.
  If solitary REAH is a relatively rare lesion, it has been demonstrated that an exhaustive sampling allows the detection of a high proportion of nasal (...)

• endobronchial lipomatous tumors

  14 October

  endobronchial lipomatous tumor
  Lipomatous lesions rarely involve the bronchial tree.
  A subset of tumors shows atypical morphologic features that would be suggestive of ALT/WDL in soft tissue sites, including regions of fibrosis and scattered hyperchromatic stromal cells.
  References
  Endobronchial Lipomatous Tumors: Clinicopathologic Analysis of 12 Cases With Molecular Cytogenetic Evidence Supporting Classification as "Lipoma". 2013. (...)

• Pulmonary neuroendocrine (NE) proliferations...

  14 October

  Pulmonary neuroendocrine (NE) proliferations are a diverse group of disorders which share distinct cytological, architectural and biosynthetic features.
  Tumours composed of NE cells are dispersed among different tumour categories in the WHO classification of tumours and as such do not conform to a singular group with regards to treatment and prognosis.
  This is reflected by the highly variable behaviour of NE proliferations, ranging from asymptomatic, for instance in diffuse idiopathic (...)

• CRTC3-MAML2

  14 October

  MAML2-CRTC3
  The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified in a large proportion of mucoepidermoid carcinomas (MECs) of the salivary gland and have impact on prognosis.
  However, there are conflicting data on the specificity of this translocation, in particular, on its putative occurrence in Warthin tumor (WT) of the parotid gland as reported in few previous cases.
  It was speculated that extensive (...)

• hypoxamiRs

  12 October

  References
  microRNAs target identification: lessons from hypoxamiRs. Bertero T, Robbe-Sermesant K, Le Brigand K, Ponzio1 G, Pottier N, Rezzonico R, Mazure NM, Barbry P, Mari B. Antioxid Redox Signal. 2013 Oct 10. PMID: #24111877#
  Hypoxamirs and Cancer: from Biology to Targeted Therapy. Gee H, Ivan C, Calin G, Ivan M. Antioxid Redox Signal. 2013 Oct 10. PMID: #24111776#

• bile miRNome

  12 October

  bile microRNAome
  References
  Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer. Shigehara K, Yokomuro S, Ishibashi O, Mizuguchi Y, Arima Y, Kawahigashi Y, Kanda T, Akagi I, Tajiri T, Yoshida H, Takizawa T, Uchida E. PLoS One. 2011;6(8):e23584. doi:10.1371/journal.pone.0023584 . PMID: #21858175# (...)

• bile

  12 October

  References
  Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer. Shigehara K, Yokomuro S, Ishibashi O, Mizuguchi Y, Arima Y, Kawahigashi Y, Kanda T, Akagi I, Tajiri T, Yoshida H, Takizawa T, Uchida E. PLoS One. 2011;6(8):e23584. doi:10.1371/journal.pone.0023584 . PMID: #21858175# [Free]

• microsatellite-stable colorectal cancer

  12 October

  References
  Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer. Bartley AN, Yao H, Barkoh BA, Ivan C, Mishra BM, Rashid A, Calin GA, Luthra R, Hamilton SR. Clin Cancer Res. 2011 Dec 1;17(23):7283-93. doi: 10.1158/1078-0432.CCR-11-1452. PMID: #21948089# [Free]

• miRNome

  12 October

  microRNAome
  MicroRNAs (miRNAs) are a class of small non-coding RNAs, which are negative regulators of gene expression.
  Pathology
  uterine leiomyoma (#22446413#)
  Many genes in human uterine leiomyoma (ULM) are aberrantly expressed and in some cases this can be due to dysregulation of miRNAs.
  More than 50 miRNAs are differentially expressed.
  The top five significantly de-regulated miRNAs in ULMs are miR-363, miR-490, miR-137, miR-217 and miR-4792.
  Some authors also observed (...)

• oncogenic signature

  12 October

  Cancer therapy is challenged by the diversity of molecular implementations of oncogenic processes and by the resulting variation in therapeutic responses.
  Projects such as The Cancer Genome Atlas (TCGA) provide molecular tumor maps in unprecedented detail. The interpretation of these maps remains a major challenge.
  Some authors distilled thousands of genetic and epigenetic features altered in cancers to ∼500 selected functional events (SFEs).
  Using this simplified description, they (...)

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