Invasion in sessile polyp
Haggitt defined the submucosal invasion in all sessile polyps as level 4 and therefore associated with bad outcome, independently of the affection or not of the resection margins.
Despite Haggitt’s classification has been widely used to evaluate the resection quality of endoscopic polypectomies, this is less useful in non-pedunculated, flat or depressed lesions.
The most accepted classification for them is Kikuchi’s one, quantifying the grade of vertical and (...)
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Invasion in sessile polyp
Nordlinger B, Guiguet M, Vaillant J, et al. Surgical resection of colorectal carcinoma metastases to the liver: a prognostic scoring system to improve case selection, based on 1568 patients. Cancer. 1996;77:1254-1262
Ueno H, Mochizuki H, Hatsuse K, et al. Indicators for treatment strategies of colorectal liver metastases. Ann Surg. 2000;231:59-66
Minagawa M, Makuuchi M, Torzilli G, et al. Extension of the frontiers of surgical indications in the treatment of liver metastases (...)
Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Scudiere JR, Shi C, Hruban RH, Herman JM, Fishman EK, Schulick RD, Wolfgang CL, Makary MA, Thornton K, Montgomery E, Horton KM. Am J Surg Pathol. 2010 Apr;34(4):447-53. PMID: #20351487#
Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity? Emory TS, Monihan JM, Carr NJ, Sobin LH. Am J Surg Pathol. 1997 Apr;21(4):392-8. PMID: (...)
Mesenteric panniculitis is a nonspecific inflammatory process affecting the fatty tissue at the root of the mesentery. This term is also used to describe the clinical and imaging findings in this disorder. Mesenteric panniculitis can be a misleading term: it is commonly misused to design an increased density of the mesentery without prejudice regarding the etiology.
Pain is the main clinical symptom. Half of the patients are asymptomatic. There is a palpable mass in half of cases. (...)
The surface mesothelial cells are several layers thick.
The surface mesothelial cells show marked nuclear irregularities, fibrin, and necrosis.
Micropapillary proliferation of irregularly shaped tubules lining the pleural surface.
Entrapped nest of mesothelial cells in the inflamed stroma.
Definition: variant of epithelioid mesothelioma with tubular architecture.
organizing fibrinous pleuritis
Mimics of sarcomatoid desmoplastic mesothelioma
fibrosis of endothoracic fascia
pleural desmoid fibromatosis
Desmoid tumors of the pleura
Desmoid tumors of the pleura are also in the differential diagnosis of desmoplastic mesothelioma. In this lesion, the proliferating cells are myofibroblasts rather than mesothelial cells, and the proliferating cells are distinguished by their morphology and by their expression of smooth muscle actin.
A pleural scar can show extension into subpleural fat and skeletal muscle. A lymphoid follicle can be seen in the pleural scar.
A subset of sarcomatoid mesotheliomas, desmoplastic mesothelioma, typically produces a dense and bland collagenous matrix that can be exceedingly difficult to distinguish from active pleural fibroplasias.
bland basket-weave fibrosis.
The entrapped spindle cells show plump nuclei and prominent nucleoli.
Possible invasion of the soft tissues of the chest wall.
Desmoplastic sarcomatoid mesothelial growth may represent the primary or (...)