Humpath.com - Human pathology

Most recent articles

• drug-induced autophagic vacuolar cardiomyopathy

  22 May

  Autophagic vacuolar cardiomyopathy is an underrecognized, but potentially fatal, complication of treatment with chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), which are used as therapy for malaria and common connective tissue disorders.
  Currently, the diagnosis of autophagic vacuolar cardiomyopathy is established through an endomyocardial biopsy and requires electron microscopy, which is not widely available and has a significant potential for sampling error. (...)

• NUP62

  22 May

  info DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, "nuclear pore glycoprotein p62", p62, SNDI; info nucleoporin 62kDa WP
  Diagnostic use
  autophagic vacuolar cardiomyopathy Autophagic vacuolar cardiomyopathy is an underrecognized, but potentially fatal, complication of treatment with chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), which are used as therapy for malaria and common connective tissue disorders. Currently, the diagnosis of autophagic vacuolar (...)

• cytoplasmic positivity of TTF-1

  22 May

  cytoplasmic positivity of TTF1 eIHC
  Cytoplasmic staining with TTF-1 has been little studied. This cytoplasmic staining is due to a cross-reacting antigen of 160 kd, which is not an alternative splicing product of TTF-115.
  In a large series of consecutive cases, about 6% (23/361) of all tumours from a variety of sites showed cytoplasmic staining.
  hepatocellular carcinoma
  a minority of pulmonary adenocarcinomas show coarse granular cytoplasmic staining
  occasionally in squamous (...)

• CA-125

  22 May

  WP PO
  CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as "mucin 16" or "MUC16" is a protein that in humans is encoded by the MUC16 gene.
  MUC16 is a member of the mucin family glycoproteins.
  CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions.

• mediastinal lymph nodes

  21 May

• Bowenoid papulosis

  20 May

  Bowenoid papulosis consists of one or more indolent, verrucous papules on the genitalia with a clinical resemblance to condyloma acuminatum and a histological resemblance to Bowen’s disease.
  HPV-16 is the most frequently detected HPV subtype detected in this condition. It usually responds to local therapies, but recurrences and the development of invasive carcinoma have been reported.
  The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive (...)

• penile intraepithelial neoplasia

  20 May

  The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive clinical entities of:
  penile Bowen disease
  erythroplasia of Queyrat
  bowenoid papulosis.

• intraepidermal carcinoma

  20 May

  intraepidermal carcinomas
  Although the term ‘intraepidermal carcinoma’ is often used synonymously with Bowen disease, it is used here in a broader sense to include not only carcinoma in situ of the skin (Bowen’s disease), and penis (erythroplasia of Queyrat), but also intraepidermal epithelioma of Jadassohn, a controversial entity of disputed histogenesis.
  Paget’s disease is sometimes included in this category because of the presence of cytologically malignant cells within the epidermis. (...)

• splenic amyloidosis

  19 May

  spleen amyloidosis
  PO
  Synopsis
  Macroscopy
  firm consistency
  waxy consistency
  possible sago spleen
  possible lardaceous spleen
  splenomegaly
  diffuse splenic infiltration
  possible localized splenic nodules
  rare splenic rupture
  Microscopy
  splenic deposition of pink amorphous material deposition of pink amorphous material limited either to germinal follicles (sago spleen) deposition of pink amorphous material along splenic sinusoids deposition of pink amorphous material in (...)

• splenic infectious mononucleosis

  18 May

  PO
  Microscopy
  expansion of red pulp immunoblastic proliferation in red pulp Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells immunoblastic infiltration of subintima of intratrabecular veins Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
  red pulp hemophagocytosis
  Differential diagnosis
  Hodgkin lymphoma
  splenic localization of leukemia
  splenic (...)

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