papillary urothelial carcinoma
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pelvic papillary urothelial carcinoma
papillary urothelial carcinoma
Low-grade papillary urothelial carcinoma shows minimal cytologic and architectural atypia. Adjacent papillary fronds may fuse.
In a low-grade papillary urothelial carcinoma, the presence of scattered hyperchromatic nuclei and typical mitotic figures distinguish this lesion from the PUNLMP.
high-grade papillary urothelial carcinoma
PUNLMP - WHO/ISUP Classification, 2004 WebPathology
Papillary urothelial neoplasms of low malignant potential (PUNLMP) show urothelial thickening but lack cytologic features of malignancy.
The image shows several papillary fragments with an orderly arrangement of cells. Umbrella cell layer can be recognized even at low magnification.
PUNLMPs are characterized by a homogenous monotonous appearance, normal to slightly enlarged nuclei and inconspicuous nucleoli. Mitotic figures are (...)
Urothelial papilloma should be distinguished from "papillary urothelial neoplasm of low malignant potential" (PUNLMP) (WHO/ISUP Classification, 1998) (formerly Grade 1 (of 3) papillary transitional cell carcinoma, WHO Classification, 1973).
Urothelial papilloma consists of papillary fronds containing delicate fibrovascular cores lined by less than 7 layers of cytologically and architecturally normal urothelium. Prominent cytoplasmic vacuoles are seen.
Using criteria (...)
transitional cell tumors
transitional cell carcinoma (TCC)
urothelial carcinoma WP
Transitional cell carcinoma (TCC), also urothelial cell carcinoma or (UCC), is a type of cancer that typically occurs in the urinary system: the kidney, urinary bladder, and accessory organs. It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus. It is the second most common type of kidney cancer, but accounts for only five to 10 percent of all primary renal malignant tumors.
TCC arises from the transitional epithelium, a (...)
Fibroepithelioma presents as a soft nodular lesion resembling a fibroma or papilloma, often on the lower part of the back.
It is composed of thin anastomosing strands of basaloid cells set in a prominent loose stroma.
The stroma has no elastic tissue.
Merkel cells are quite prominent.
It has been suggested, and subsequently disputed, that this variant derives its histological pattern from the spread of basal cell carcinoma down eccrine ducts, eventually replacing them with solid strands (...)
Basosquamous carcinoma is a controversial entity which can be defined as a basal cell carcinoma differentiating into a squamous cell carcinoma.
It is composed of three types of cell:
basaloid cells, which are slightly larger, paler and more rounded than the cells of a solid basal cell carcinoma;
squamoid cells with copious eosinophilic cytoplasm;
an intermediate cell which resembles that seen in metatypical tumors.
Accordingly, the basosquamous carcinoma is sometimes confused with (...)
Although the term ’metatypical’ is sometimes applied to tumors with mixed basaloid and squamous features, it should be reserved for the rare basal cell carcinoma composed of nests and strands of cells maturing into larger and paler cells.
Peripheral palisading is often lost.
The cells express much less keratin 17 and keratin 8 than do the cells in the more usual types of basal cell carcinoma.
Peripheral palisading is less obvious than usual, and the stroma is often (...)
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