Mucous cells in CPAM
Adenocarcinomas expressing gastric mucins often are accompanied by ectopic gastric mucosa or pyloric metaplasia. Mucinous bronchioloalveolar carcinoma (mucinous BAC) producing gastric mucins have been described.
In the lung tissue, mucous cells seemingly similar to gastric mucous cells are present in congenital adenomatoid malformation (CAM).
Mucous cells are detected in 40% of CPAM . These mucous cells displayed papillary growth in cystic spaces and proliferated along alveolar walls. Mucous cells in the papillary, configuration stained with galactose oxidase cold thionine Schiff reaction.
Mucous cells in CAM are identical to those of pyloric mucosa and could be considered candidates for the origin of mucinous BAC producing gastric mucins.
References
Histochemical analysis of mucous cells of congenital adenomatoid malformation of the lung: insights into the carcinogenesis of pulmonary adenocarcinoma expressing gastric mucins. Ota H, Langston C, Honda T, Katsuyama T, Genta RM. Am J Clin Pathol. 1998 Oct;110(4):450-5. PMID: 9763030