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Friday 27 October 2006

Pseudogenes have long been considered to be ’dead’, nonfunctional by-products of genome evolution.

Some pseudogenes are transcriptionally ’alive’, and a few might even have biochemical roles. Therefore, the boundary between genes (often considered to be ’living’) and pseudogenes (often considered to be ’dead’) might be ambiguous and difficult to define.


- Zheng D, Gerstein MB. The ambiguous boundary between genes and pseudogenes: the dead rise up, or do they? Trends Genet. 2007 Mar 21; PMID: 17382428

- Pavlicek A, Gentles AJ, Paces J, Paces V, Jurka J. Retroposition of processed pseudogenes: the impact of RNA stability and translational control. Trends Genet. 2006 Feb;22(2):69-73. PMID: 16356584