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TRAF1

MIM.601711 9q33-q34

Tuesday 4 December 2007

Pathology

- The expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma (ALCL), nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), and nonmediastinal diffuse large B-cell lymphoma (DLBCL). (17197926)

References

- Rodig SJ, Savage KJ, Lacasce AS, Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, Kutok JL. Expression of TRAF1 and Nuclear c-Rel Distinguishes Primary Mediastinal Large Cell Lymphoma From Other Types of Diffuse Large B-cell Lymphoma. Am J Surg Pathol. 2007 Jan;31(1):106-112. PMID: 17197926