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Friday 2 December 2016

Myelin and lymphocyte (MAL) protein


The MAL protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids.

The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function.

The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains.

Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

The MAL protein is also thought to interact with the protein encoded by LSMEM1 based on two-hybrid screening.


Myelin and lymphocyte (MAL) protein has been previously reported as a highly specific marker for distinguishing primary mediastinal large B-cell lymphoma (PMBL) from diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS).

There is a high specificity with good sensitivity in distinguishing PMBL from DLBCL, NOS, similar to previous studies with a noncommercial source.

Paywall references

Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma. Gentry M, Bodo J, Durkin L, Hsi ED. Am J Surg Pathol. 2016 Nov 22. PMID: 27879516