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Home > D. General pathology > Genetic and developmental anomalies > Chromosomal diseases > Constitutional translocations > t(3;8)(p14.2;q24.1)


Thursday 14 June 2007

The t(3;8)(p14;q24.1) translocation fuses FHIT at 3p14 with the patched-related gene TRC8 at 8q24.1 (9689122) with formation of the TRC8/FHIT fusion gene).

- TRC8 gene can be interrupted by a t(3;8)(p14.2;q24.1) translocation in


- Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin HA, Gemmill RM, Plon SE. A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. Genes Chromosomes Cancer. 2007 May 30; PMID: 17539022