fusion gene

Definition: Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis. In 2007, 358 gene fusions involving 337 different genes have been identified.

See list

An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas.

The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated.

However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity.

See also

 gene fusions in sarcomas
 gene fusions in leukemias and lymphomas
 gene fusions in carcinomas

Types

 fusion genes involving tyrosine kinases
 fusion genes involving transcription factors

Common fusion gene in different tumors

 EWSR1/CREB1 fusion gene in

• angiomatoid fibrous histiocytoma (17724745)
• clear cell sarcoma (17000668)

 ETV6/NTRK3 fusion gene in

• congenital fibrosarcoma
• cellular mesoblastic nephroma

Database

 FusionCancer : http://omictools.com/fusioncancer-s10662.html

See also

 amplification of fusion genes
 fusion transcripts
 fusion proteins
 tumoral translocations

Open references

 TumorFusions: an integrative resource for cancer-associated transcript fusions. 2017. doi : 10.1093/nar/gkx1018

• https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkx1018/4584571

 FusionCancer: a database of cancer fusion genes derived from RNA-seq data. Wang Y, Wu N, Liu J, Wu Z, Dong D. Diagn Pathol. 2015 Jul 28;10:131. doi : 10.1186/s13000-015-0310-4 PMID: 26215638
URL : http://omictools.com/fusioncancer-s10662.html

Reviews

 Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007 Apr;7(4):233-45. PMID: 17361217

References

 Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007 Aug 20; PMID: 17724745

 Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma—association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 2006; 12: 5356-5362. Medline 17000668

 Aman P. Fusion genes in solid tumors. Semin Cancer Biol. 1999 Aug;9(4):303-18. PMID: 10448117