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DNAH5

MIM.603335 5p15-p14

Tuesday 24 July 2007

DYneins

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains.

The dynein heavy chains (DNAHs) are responsible for force production and ATPase activity and contain a highly conserved catalytic domain with 4 P-loop consensus motifs involved in nucleotide binding.

Two major classes of dyneins, axonemal dyneins and cytoplasmic dyneins, have been identified.

Pathology

- germline mutations in

See also

- DNAHs (dynein heavy chains)

  • DNAH1 (MIM.603332), DNAH2, DNAH3, DNAH4, DNAH5, DNAH6 (MIM.603336), DNAH7, DNAH8, DHAH9 (MIM.603338), DNAH10, DNAH11, DNAH12 (MIM.603340), DNAH13, and DNAH14