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Home > A. Molecular pathology > CREB1-EWSR1


Wednesday 29 August 2007


Fusion gene fornation by translocation

CREB1 at 2q32-q34 and EWSR1 at 22q12


- clear cell sarcoma ( soft parts melanoma ) (17000668)
- angiomatoid fibrous histiocytoma (AFH) (17724745)
- Ewing sarcoma / small blue round cell tumor (20598147)

See also


Open references

- Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report. Pacheco M, Horsman DE, Hayes MM, Clarkson PW, Huwait H, Nielsen TO. Mol Cytogenet. 2010 Jul 2;3:12. doi : 10.1186/1755-8166-3-12 PMID: 20598147 Free

Paywall References

- Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma—association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res. 2006 Sep 15;12(18):5356-62. PMID: 17000668

- Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007 Aug 20; PMID: 17724745