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poorly differentiated thyroid carcinoma

Friday 5 October 2007

thyroid poorly differentiated carcinoma ; PDTC

Definition: Poorly differentiated thyroid carcinomas (PDTC) lie both morphologically and behaviorally between well-differentiated and undifferentiated carcinomas (anaplastic thyroid carcinoma / ATC ) .

Images

- Poorly differentiated thyroid carcinoma with pulmonarynodules

Turin criteria - Turin proposal

A consensus meeting was held in Turin, Italy, where an agreement was reached concerning the diagnostic criteria for poorly differentiated carcinoma (17667551). These include :
- (1) presence of a solid/trabecular/insular pattern of growth,
- (2) absence of the conventional nuclear features of papillary carcinoma,
- (3) presence of at least one of the following features:

  • convoluted nuclei;
  • mitotic activity >or=3 x 10 HPF;
  • tumor necrosis.

See also

- thyroid carcinomas / thyroid gland carcinomas

  • insular thyroid carcinoma (ITC)
  • anaplastic thyroid carcinoma (ATC)

Paywall references

- Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J. Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol. 2007 Aug;31(8):1256-64. PMID: 17667551

- Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours.
Volante M, Papotti M.
Endocr Pathol. 2010 Mar;21(1):1-6. doi : 10.1007/s12022-009-9100-4
PMID: 19960273

- Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours.
Volante M, Papotti M.
Endocr Pathol. 2010 Mar;21(1):1-6. doi : 10.1007/s12022-009-9100-4
PMID: 19960273

- Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.
Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J.
Am J Surg Pathol. 2007 Aug;31(8):1256-64.
PMID: 17667551

- Prognostic factors of clinical interest in poorly differentiated carcinomas of the thyroid.
Volante M, Cavallo GP, Papotti M.
Endocr Pathol. 2004 Winter;15(4):313-7. Review.
PMID: 15681855