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Friday 19 October 2007

Both the salvage and de novo synthesis pathways of purine and pyrimidine biosynthesis lead to production of nucleoside-5’-phosphates through the utilization an activated sugar intermediate and a class of enzymes called phosphribosyltransferases.

The activated sugar used is 5-phospho—D-ribosyl-1-pyrophosphate, PRPP: PRPP is generated by the action of PRPP synthetase and requires energy in the form of ATP as shown:

ribose-5-phosphate + ATP -------> PRPP + AMP

This reaction releases AMP. Therefore, 2 high energy phosphate equivalents are consumed during the reaction.

See also

- purine metabolism