Humpath.com - Human pathology

Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(10;17)(q22;p13)

t(10;17)(q22;p13)

Friday 21 December 2007

Tumors

- clear cell sarcoma of kidney (CCSK) (15474157)

- endometrial stromal sarcoma (ESS) (23599159)

  • YWHAE-FAM22 fusion gene in endometrial stromal sarcoma by t(10;17)(q22;p13)
  • YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas (23599159)
  • Endometrial stromal sarcomas represent the second most common mesenchymal uterine tumor.
  • The 2003 WHO classification distinguishes low-grade and undifferentiated endometrial stromal sarcomas with different prognoses.
  • Endometrial stromal sarcomas are a genetically heterogeneous group of sarcomas harboring different cytogenetic anomalies.
  • A fusion between the YWHAE and FAM22A/B genes subsequent to a t(10;17) (q22;p13) has been described in endometrial sarcomas with high-grade histology.

References

- YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations. Croce S, Hostein I, Ribeiro A, Garbay D, Velasco V, Stoeckle E, Guyon F, Floquet A, Neuville A, Coindre JM, Macgrogan G, Chibon F. Mod Pathol. 2013 Apr 19. doi : 10.1038/modpathol.2013.69 PMID: 23599159

- Rakheja D, Weinberg AG, Tomlinson GE, Partridge K, Schneider NR. Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. Cancer Genet Cytogenet. 2004 Oct 15;154(2):175-9. PMID: 15474157