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genome annotation

Tuesday 21 October 2003

The sequencing of large, complex genomes has become routine, but understanding how sequences relate to biological function is less straightforward.

Although much attention is focused on how to annotate genomic features such as developmental enhancers and non-coding RNAs, there is still no higher eukaryote for which we know the correct exon-intron structure of at least one ORF for each gene.

References

- Brent MR. Steady progress and recent breakthroughs in the accuracy of automated genome annotation. Nat Rev Genet. 2008 Jan;9(1):62-73. PMID: 18087260

- Reed JL, Famili I, Thiele I, Palsson BO. Towards multidimensional genome annotation. Nat Rev Genet. 2006 Feb;7(2):130-41. PMID: 16418748

- Stein L. Genome annotation: from sequence to biology. Nat Rev Genet. 2001 Jul;2(7):493-503. PMID: 11433356

- Doerks T, Bairoch A, Bork P. Protein annotation: detective work for function prediction. Trends Genet. 1998 Jun;14(6):248-50. PMID: 9635409