- Human pathology

Home > A. Molecular pathology > CDs > CD38


Wednesday 14 May 2008


Definition: CD38 is an ectoenzyme involved in transmembrane signaling and cell adhesion and is used as a disease marker for leukemias and myeloma.


- CLL / chronic lymphocytic leukemia

  • CD38 is a dependable negative prognostic marker for chronic lymphocytic leukemia (CLL).
  • CD38 is a component of a complex network delivering growth and survival signals to CLL cells. In conjunction with chemokines and their receptors, CD38 also influences cell migratory responses.

Targeted therapy

- anti-CD38 antibody


- Deaglio S, Aydin S, Vaisitti T, Bergui L, Malavasi F. CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med. 2008 May;14(5):210-8. PMID: 18403265