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hemosiderotic fibrolipomatous tumor

Monday 19 May 2008

haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL); HFLT

Definition: Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature.




- reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3 (18406878)

- aberrations of chromosome 3

Some soft tissue tumors can show hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor with a der(10)t(1;10), and abnormalities of chromosome 3. These hybrid lesions provide further evidence for a close relationship between these 2 tumor types. Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are both rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. (20871391)

Molecular Pathology

- t(1;10)(p22;q24) with gene fusion of TGFBR3 and MGEA5 in myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. (21717526)

Open References

- Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.
Antonescu CR, Zhang L, Nielsen GP, Rosenberg AE, Dal Cin P, Fletcher CD.
Genes Chromosomes Cancer. 2011 Oct;50(10):757-64. doi : 10.1002/gcc.20897
PMID: 21717526

See also

- myxoinflammatory fibroblastic sarcoma


- Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link. Elco CP, Mariño-Enríquez A, Abraham JA, Dal Cin P, Hornick JL. Am J Surg Pathol. 2010 Nov;34(11):1723-7. PMID: 20871391

- Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. Hallor KH, Sciot R, Staaf J, Heidenblad M, Rydholm A, Bauer HC, Aström K, Domanski HA, Meis JM, Kindblom LG, Panagopoulos I, Mandahl N, Mertens F. J Pathol. 2009 Apr;217(5):716-27. PMID: 19199331

- Wettach GR, Boyd LJ, Lawce HJ, Magenis RE, Mansoor A. Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor. Cancer Genet Cytogenet. 2008 Apr 15;182(2):140-3. PMID: 18406878

- Browne TJ, Fletcher CD. Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology. 2006 Mar;48(4):453-61. PMID: 16487368