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ALDH1A1

Thursday 10 July 2008

Acetaldehyde dehydrogenase (EC 1.2.1.3) is the next enzyme after alcohol dehydrogenase (MIM.103700) in the major pathway of alcohol metabolism.

Pathology

- ovarian high-grade serous carcinoma (25216223)

  • Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma. (25216223)
  • ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. (22144423)
  • In mice, stem cells at the ovarian hilum have been shown to express the stem cell marker, aldehyde dehydrogenase isoform 1A1 (ALDH1A1), and are prone to malignant transformation.
  • The Cancer Genome Atlas revealed downregulation of ALDH1A1 transcripts in high-grade serous carcinoma relative to normal tubal epithelium, and no association between ALDH1A1 expression levels and overall survival.
  • Some results do not support ALDH1A1 as a specific marker of stem cells in human fallopian tube and demonstrate that its loss of expression is an early event in the development of high-grade serous carcinoma. (25216223)

- breast cancer

  • Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. (22652835)

Open references

- Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma. Chui MH, Wang Y, Wu RC, Seidman J, Kurman RJ, Wang TL, Shih IeM. Mod Pathol. 2015 Mar;28(3):437-45. doi : 10.1038/modpathol.2014.89 PMID: 25216223 (Free)

- Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. Khoury T, Ademuyiwa FO, Chandraseekhar R, Jabbour M, Deleo A, Ferrone S, Wang Y, Wang X. Mod Pathol. 2012 Jun;25(6):917. PMID: 22652835 (Free)

- ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. Li H, Bitler BG, Vathipadiekal V, Maradeo ME, Slifker M, Creasy CL, Tummino PJ, Cairns P, Birrer MJ, Zhang R. Cancer Prev Res (Phila). 2011 Dec 5. PMID: 22144423

- Douville J, Beaulieu R, Balicki D. ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells. Stem Cells Dev. 2008 Jun 23. PMID: 18573038

- Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G. ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome. Cell Stem Cell. 2007 Nov 15;1(5):555-567. PMID: 18371393

- Balicki D. Moving Forward in Human Mammary Stem Cell Biology and Breast Cancer Prognostication Using ALDH1. Cell Stem Cell. 2007 Nov 15;1(5):485-487. PMID: 18371386

- Goedde, H. W.; Agarwal, D. P.; Harada, S.; Meier-Tackmann, D.; Ruofu, D.; Bienzle, U.; Kroeger, A.; Hussein, L. : Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am. J. Hum. Genet. 35: 769-772, 1983. PubMed ID : 6881146