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chenodeoxycholic acid

Wednesday 30 July 2008

Definition: Chenodeoxycholic acid (also known as chenodesoxycholic acid) is a bile acid. Chenodeoxycholic acid is one of the 4 main organic acids produced by the liver. Chenodeoxycholic acid and cholic acid are the most important human bile acids. Some other mammals synthesize predominantly deoxycholic acid.

Salts of this carboxylic acid are called chenodeoxycholates.

Chenodeoxycholic acid is synthesized in the liver from cholesterol.

This compound, when altered by bacteria in the colon, will result in conversion to its secondary bile acid known as lithocholic acid. Both of these bile acids, in addition to the others, can be conjugated to taurine or glycine.

Conjugation, a function carried out by the liver will result in a lowered pKa and therefore, the compounds will remain ionized. These ionized compounds will stay in the gastrointestinal tract until reaching the ileum where they will be reabsorbed.

The purpose of this conjugation is to keep the bile acids in the tract until the end to facilitate lipid digestion all the way to the ileum.

Deconjugation

In cases where bacteria overgrow in the small intestine, often due to a blind loop in the intestine retaining chyme in one place, the bacteria will de-conjugate the bile acids and therefore impede fat digestion and absorption. This can lead to steatorrhea.

See also

- bile acids