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premature aging diseases

Tuesday 28 October 2003

premature ageing disorders, premature aging, premature aging syndromes, premature aging disorders: Accelerated aging disease ; progeroid syndroms

WKP

Definition: Progeroid syndromes (PS) are a group of rare genetic disorders which mimic physiological aging, making affected individuals appear to be older than they are.

The term progeroid syndrome does not necessarily imply progeria (Hutchinson–Gilford progeria syndrome), which is a specific type of progeroid syndrome.

Types

- progeroid syndroms

- dyskeratosis congenita
-* NHP2 mutations (18523010)

References

- Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 2006 Jul;12(7):298-305. PMID: 16731043

- Chang S. Modeling premature aging syndromes with the telomerase knockout mouse. Curr Mol Med. 2005 Mar;5(2):153-8. PMID: 15974868

- Novelli G, D’Apice MR. The strange case of the "lumper" lamin A/C gene and human premature ageing. Trends Mol Med. 2003 Sep;9(9):370-5. PMID: 13129702

- Bohr VA: Human premature aging syndromes and genomic instability. Mech Ageing Dev 123:987, 2002.