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STATs

Wednesday 29 October 2003

Definition: The signal transducer and activator of transcription (STATs) proteins are latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease.

Members

STAT1 STAT2 STAT3 STAT4 STAT5 STAT6

IHC Markers

- STAT6 in solitary fibrous tumor

See also

- JAKs
- JAKs/STATs signaling pathways

References

- Clevenger CV. Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol. 2004 Nov;165(5):1449-60. PMID: 15509516

- Yu H, Jove R. The STATs of cancer—new molecular targets come of age. Nat Rev Cancer. 2004 Feb;4(2):97-105. PMID: 14964307

- Battle TE, Frank DA. The role of STATs in apoptosis. Curr Mol Med. 2002 Jun;2(4):381-92. PMID: 12108949

- Aaronson DS, Horvath CM. A road map for those who don’t know JAK-STAT. Science. 2002 May 31;296(5573):1653-5. PMID: 12040185

- Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62. PMID: 12209125