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cortical degenerative disease

Tuesday 14 April 2009

The major cortical degenerative disease is Alzheimer disease, and its principal clinical manifestation is dementia, that is, progressive loss of cognitive function independent of the state of attention.

There are many other causes of dementia, including the various forms of frontotemporal dementia, vascular disease (multi-infarct dementia), dementia with Lewy bodies (considered later in the context of Parkinson disease, the other Lewy body disorder), Creutzfeldt-Jakob disease, and neurosyphilis (both considered earlier).

These diseases also involve subcortical structures, but many of the clinical symptoms are related to the changes in the cerebral cortex. Regardless of etiology, dementia is not part of normal aging and always represents a pathologic process.