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cellular angiofibroma

Monday 27 April 2009


Definition: Cellular angiofibroma is a rare benign mesenchymal tumour of middle-aged adults. This tumour is usually located in the vulvovaginal or inguinoscrotal region.


- Cellular Angiofibroma (Angiomyofibroblastoma-like Tumor of Male Genital Tract)

Cellular angiofibroma is a mesenchymal neoplasm that is characterized by a bland spindle cell component, morphologically reminiscent of spindle cell lipoma, and thick-walled vessels. The tumor occurs equally in men and women and usually arises in the inguino-scrotal or vulvovaginal regions.

Cellular angiofibroma occurs in adults of either sex, principally in the vulvovaginal and inguinoscrotal regions.

Differential diagnosis

- spindle cell lipoma

  • It shows morphological similarities to spindle cell lipoma

- aggressive angiomyxoma

  • usually large and deep, hypocellular, infiltrative margin, desmin+

- angiomyofibroblastoma

  • less uniform cellularity, smaller vessels, usually desmin+
  • leiomyoma : spindled cytoplasm, actin+, desmin+
  • perineurioma
  • PHAT
    - solitary fibrous tumor
  • hyper- and hypocellular areas, prominent staghorn vessels, hyalinized collagen CD34+


- cellular angiofibroma with atypia (20305534)
- sarcomatous transformation in a cellular angiofibroma. (19783726)

  • Cellular angiofibroma with atypia or morphologic sarcomatous transformation occurs predominantly in the subcutaneous tissue of the vulva and, as yet, shows no evident tendency to recur based on limited clinical follow-up available for 7 cases.
  • The sarcomatous component can show variable features including atypical lipomatous tumor, pleomorphic liposarcoma, and pleomorphic sarcoma NOS. Overexpression of p16 in the atypical cells and sarcomatous component suggests a possible underlying molecular mechanism.


- Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Chen E, Fletcher CD. Am J Surg Pathol. 2010 May;34(5):707-14. PMID: 20305534

- Sarcomatous transformation in a cellular angiofibroma: a case report. Kandil DH, Kida M, Laub DR, Cooper K. J Clin Pathol. 2009 Oct;62(10):945-7. PMID: 19783726