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IgG4-associated mastitis

Thursday 30 April 2009

Immunoglobulin G (IgG)4-related sclerosing disease is a recently described syndrome characterized by mass-forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, elevated serum IgG4 titer, increased tissue IgG4 plasma cells, and favorable clinical outcome. IgG4-related sclerosing mastitis is one of the possible localization.

IgG4-related sclerosing mastitis appears to be a distinctive form of mastitis, sometimes accompanied by other components of IgG4-related sclerosing disease, and shows a favorable clinical outcome. (19384187)


- IgG4-related Sclerosing Mastitis: Description of a New Member of the IgG4-related Sclerosing Diseases. Cheuk W, Chan AC, Lam WL, Chow SM, Crowley P, Lloydd R, Campbell I, Thorburn M, Chan JK. Am J Surg Pathol. 2009 Apr 18. PMID: 19384187