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calcifying odontogenic tumor

Sunday 10 May 2009

Calcifying epithelial odontogenic tumor, Pindborg tumor; Calcifying epithelial odontogenic tumor

Definition: Calcifying odontogenic tumor is an epithelial odontogenic tumor characterized by sheets of hyperchromatic, ovoid and squamous cells with foci of mineralization and amyloid.


- Calcifying epithelial odontogenic (Pindborg) tumor in maxilla. Amyloid deposits & Liesegang rings

They occur more often in the mandible than the maxilla (2:1). They tend to be in the molar and premolar region and there is a bimodal age pattern, with a slight increase in tumors reported during the 20’s and again during the 40’s.

Radiographically they are well circumscribed corticated, unilocular or multilocular radiolucencies. Small radio-opacities may be detected.

Microscopically they show island and sheets of polygonal, epithelial cells showing foci of remarkable pleomorphism and nuclear hyperchromasia. Prominent intracellular bridges are seen and amyloid is present. Foci of mineralization are seen.

These tumors respond to conservative surgical removal and recurrence rates are less than 10%.


- Cystic variant of calcifying epithelial odontogenic tumor. Gopalakrishnan R, Simonton S, Rohrer MD, Koutlas IG. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Dec;102(6):773-7. PMID: 17138180

- Recurrent calcifying odontogenic cyst involving the maxillary sinus. Daniels JS. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):660-4. PMID: 15583537