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pyruvate dehydrogenase

Friday 22 May 2009

The multienzyme complex pyruvate dehydrogenase is at the junction of glycolysis and the citric acid cycle.

It requires five organic cofactors and one metal ion : loosely bound thiamine diphosphate (ThDP), covalently bound lipoamide and flavin adenine dinucleotide (FAD), and the cosubstrates nicotinamide adenine dinucleotide (NAD+) and coenzyme A (CoA) and a metal ion (Mg2+).

Pathology

- pyruvate dehydrogenase deficiency