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DNA methylation study

Wednesday 29 October 2003

Methods

- methylation-specific PCR
- mcrBC/HpaII screening method
- bisulfite sequencing
- high-throughput DNA methylation profiling
- DNA methylation by pyrosequencing

Biotechnology companies

- Varionostic

See also

- DNA methylation
- pyrosequencing
- high-throughput DNA methylation profiling

References

- Impact of sample heterogeneity on methylation analysis. Loh M, Liem N, Lim PL, Vaithilingam A, Cheng CL, Salto-Tellez M, Yong WP, Soong R. Diagn Mol Pathol. 2010 Dec;19(4):243-7. PMID: 21051995

- Ushijima T. Detection and interpretation of altered methylation patterns in cancer cells. Nat Rev Cancer. 2005 Mar;5(3):223-31. PMID: 15719030

- Lindsey JC, Lusher ME, Anderton JA, Bailey S, Gilbertson RJ, Pearson AD, Ellison DW, Clifford SC. Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis. 2003 Dec 19 PMID: 14688019

- Laird PW. The power and the promise of DNA methylation markers. Nat Rev Cancer. 2003 Apr;3(4):253-66. PMID: 12671664