pancreatic ductal adenocarcinoma
Wednesday 29 October 2003
exocrine pancreatic cancer, pancreatic adenocarcinomas, pancreatic cancer; pancreas cancer
Definition: Pancreatic adenocarcinoma is the fifth leading cause of cancer death with a 5-year survival rate of less than 5%.
genic inactivations by somatic mutations
- p53 (TP53) at 17p13.1 (MIM.191170) (25%)
- MADH4 (DPC4 or SMAD4) at 18q21.1 (MIM.600993) (8%)
- p16 (CDKN2A or MTS1) at 9p21 (MIM.600160)
- ACVR1B at 12q13 (MIM.601300)
- K-RAS (KRAS2) at 12q12.1 (MIM.190070) (78%)
KRAS/TP53-associated pancreatic adenocarcinoma
Genetic risk factors are believed to play a major role. Approximately 10% of PC is estimated to have familial inheritance.
Several germline mutations have been found to be involved in hereditary forms of PC, including both familial PC (FPC) and PC as one of the manifestations of a hereditary cancer syndrome or other hereditary conditions.
Candidate genes have been described and patients considered for screening programs under research protocols should first be tested for presence of germline mutations in the BRCA2, PALB2 and ATM genes. In specific PC populations, including in Italy, hereditary cancer predisposition genes such as CDKN2A also explain a considerable fraction of FPC. (25152581)
Candidate genes: BRCA2, PALB2, ATM, CDKN2A. (25152581)
See: familial pancreatic cancer
Pancreatic adenocarcinoma by Washington Deceit (1)
Pancreatic adenocarcinoma by Washington Deceit (2)
Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma.
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Clin Chem. 2015 Nov;61(11):1408-16. doi : 10.1373/clinchem.2015.238543
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