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CD138

Wednesday 21 October 2009

Definition: CD138 (Aka heparan sulfate proteoglycan, syndecan-1) mediates cell adhesion, growth factors. It is associated with late stage of B cell differentiation. CD138 is an integral membrane protein is a receptor for extracellular matrix. Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. Syndecan 1 is a protein which in humans is encoded by the SDC1 gene.

CD138 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein.

The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins.

While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Immunochemistry

- Positive staining in normal cells

  • B cell precursors
  • plasma cells
  • stratified squamous epithelium

- Positive staining in tumors

  • keratoacanthoma
  • myeloma
  • plasmablastic lymphoma (strong)
  • primary effusion lymphoma
  • pyothorax associated lymphoma
  • CD138+ carcinomas

- Negative staining

  • mature B cells
  • other lymphomas (even plasmacytoid lymphomas)

Pathology

- Altered syndecan-1 expression has been detected in several different tumor types.

- Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC-in situ.

Links

- Wikipedia

See also

- CDs