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TLE1

MIM.600189 9q21.32 HGNC:11837

Monday 16 November 2009

WKP

Definition: Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene. TLE1 encodes a transcriptional corepressor

Pathology

- TME is overexpressed in synovial sarcomas.

  • TME is a IHC marker of synovial sarcoma.
  • TLE1 is an excellent bio-marker for distinguishing the synovial sarcoma from other soft tissue malignancies.

- Transducer-like Enhancer of Split 1 (TLE1) is expressed in Follicular Dendritic Cells (FDCs) and Follicular Dendritic Cell Tumors (FDCTs).

Interactions

TLE1 has been shown to interact with:
Glycoprotein 130
HES6
RUNX1
RUNX3
SIX3
TLE2
UTY

References

- Prospective Evaluation of TLE1 as a Diagnostic Immunohistochemical Marker in Synovial Sarcoma. Jagdis A, Rubin BP, Tubbs RR, Pacheco M, Nielsen TO. Am J Surg Pathol. 2009 Oct 3. PMID: 19809272