Humpath.com - Human pathology

Home > A. Molecular pathology > CCL21

CCL21

Friday 6 January 2017

WKP

Definition: Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family of chemokines.

CCL21 chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).

The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

Pathology

- CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders. (17495955)

Open references

- CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders.
Ohmatsu H, Sugaya M, Kadono T, Tamaki K.
J Invest Dermatol. 2007 Oct;127(10):2466-8.
PMID: 17495955 Free