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Thymus in Langerhans histiocytosis

Friday 15 January 2010


Extensive medullary infiltration by typical Langerhans histiocytes can be associated with active destruction of thymic epithelium, medullary pseudocysts, and prevalence of calcospherites, some of which were in Langerhans histiocytes.

The presence of minimally affected Hassall bodies indicates that the thymus is probably normal prior to onset of disease.

Destruction of thymic epithelium occurs regularly in Langerhans histiocytosis, but it may be an insignificant epiphenomenon resulting from the affinity of Langerhans histiocytes for squamous epithelium.


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- A clinicopathological study of histiocytosis X. Tsunematsu Y, Koide R, Watanabe S, Takahashi H, Morikawa Y, Shimizu K. Jpn J Clin Oncol. 1984 Dec;14(4):633-46. PMID: 6335190

- Thymic changes in histiocytosis. Hamoudi AB, Newton WA Jr, Mancer K, Penn GM. Am J Clin Pathol. 1982 Feb;77(2):169-73. PMID: 6978063