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EPCAM

HGNC:11529 2p21 Entrez:4072 MIM.185535

Thursday 4 February 2010

MOC31; M4S1, MIC18, TACSTD1; epithelial cell adhesion molecule; CD326; tumor-associated calcium signal transducer 1; antibody BerEP4

WP MIM:185535 HGNC:11529

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia.

EpCAM is also involved in cell signaling, migration, proliferation, and differentiation.

Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.

Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers.

Pathology

- germline mutations in congenital tufting enteropathy (MIM.613217)

- overexpression in cancers

- prognosis underexpression in RCC

  • A negative EPCAM IHC was found in 1/3 of the patients and was associated with high-grade disease and nodal metastases. (23180689)
  • Kaplan-Meier analyses demonstrated a significant association between positive EPCAM IHC and prolonged overall survival, even in a subset of low risk ccRCC. (23180689)
  • In multivariable analyses, EPCAM represented an independent risk factor of survival throughout all subgroups. (23180689)
  • For localized, low-grade ccRCC, information of EPCAM IHC raised predictive accuracy of a multivariate model by ∼5%, compared to T-stage and grade alone. (23180689)
  • EPCAM is an independent prognostic molecular marker in ccRCC and, especially in localized ccRCC, might be able to provide auxiliary information for a better prognostication. (23180689)

IHC

- BerEP4 monoclonal antibody

See also

- SPINT2

  • SPINT2-associated tufting enteropathy (20009592)

References

- Epithelial cell adhesion molecule (EPCAM) is an independent prognostic marker in clear cell renal carcinoma. Eichelberg C, Chun FK, Bedke J, Heuer R, Adam M, Moch H, Terracciano L, Hinrichs K, Dahlem R, Fisch M, Schlomm T, Sauter G, Minner S. Int J Cancer. 2012 Nov 26. PMID: 23180689

- Further evidence for EpCAM as the gene for congenital tufting enteropathy. Sivagnanam M, Schaible T, Szigeti R, Byrd RH, Finegold MJ, Ranganathan S, Gopalakrishna GS, Tatevian N, Kellermayer R. Am J Med Genet A. 2010 Jan;152A(1):222-4. PMID: 20034091

- Further evidence for EpCAM as the gene for congenital tufting enteropathy. Sivagnanam M, Schaible T, Szigeti R, Byrd RH, Finegold MJ, Ranganathan S, Gopalakrishna GS, Tatevian N, Kellermayer R. Am J Med Genet A. 2010 Jan;152A(1):222-4. PMID: 20034091

- Al-Mayouf, S. M.; Alswaied, N.; Alkuraya, F. S.; AlMehaidib, A.; Faqih, M. : Tufting enteropahty and chronic arthritis: a newly recognized association with a novel EpCAM gene mutation. J. Pediat. Gastroent. Nutr. 49: 642-644, 2009. PubMed ID : 19820410

- Expression of EpCam and villin in Barrett’s esophagus and in gastric cardia. Anders M, Sarbia M, Grotzinger C, Meining A, Hofler H, Wiedenmann B, Rosch T. Dis Markers. 2008;24(6):287-92. PMID: 18688077

- Identification of EpCAM as the gene for congenital tufting enteropathy. Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, Zlotkin SH, Pencharz PB, Ngan BY, Libiger O, Schork NJ, Lavine JE, Taylor S, Newbury RO, Kolodner RD, Hoffman HM. Gastroenterology. 2008 Aug;135(2):429-37. Epub 2008 May 15. PMID: 18572020

- Limited suitability of EpCAM for molecular staging of tumor borders in head and neck cancer. Andratschke M, Hagedorn H, Luebbers CW, Schmitt B, Lang S, Zeidler R, Wollenberg B. Anticancer Res. 2006 Jan-Feb;26(1A):153-8. PMID: 16475692

- The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Münz M, Zeidler R, Gires O. Cancer Lett. 2005 Jul 8;225(1):151-7. PMID: 15922867

- The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Münz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O. Oncogene. 2004 Jul 29;23(34):5748-58. PMID: 15195135

- Prognostic significance of Ep-CAM AND Her-2/neu overexpression in invasive breast cancer. Spizzo G, Obrist P, Ensinger C, Theurl I, Dünser M, Ramoni A, Gunsilius E, Eibl G, Mikuz G, Gastl G. Int J Cancer. 2002 Apr 20;98(6):883-8. PMID: 11948467

- The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung. Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE. Hum Pathol. 2000 Apr;31(4):482-7. PMID: 10821496

- Ep-Cam levels in prostatic adenocarcinoma and prostatic intraepithelial neoplasia. Poczatek RB, Myers RB, Manne U, Oelschlager DK, Weiss HL, Bostwick DG, Grizzle WE. J Urol. 1999 Oct;162(4):1462-6. PMID: 10492238

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- Sivagnanam, M.; Mueller, J. L.; Lee, H.; Chen, Z.; Nelson, S. F.; Turner, D.; Zlotkin, S. H.; Pencharz, P. B.; Ngan, B.-Y.; Libiger, O.; Schork, N. J.; Lavine, J. E.; Taylor, S.; Newbury, R. O.; Kolodner, R. D.; Hoffman, H. M. : Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology 135: 429-437, 2008. PubMed ID : 18572020

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