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genome-wide DNA methylation analysis

Sunday 7 March 2010

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.

Therefore, profiling DNA methylation across the genome is vital to understanding the influence of epigenetics.

There has been a revolution in DNA methylation analysis technology over the past decade: analyses that previously were restricted to specific loci can now be performed on a genome-scale and entire methylomes can be characterized at single-base-pair resolution.

References

- Principles and challenges of genome-wide DNA methylation analysis. Laird PW. Nat Rev Genet. 2010 Feb 2;11(3):191-203. PMID: #20125086#