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rectal carcinoma

Saturday 13 March 2010

Preoperative 5-fluorouracil-based radiochemotherapy (RCT), followed by total mesorectal excision, is accepted as standard therapy in rectal cancers (UICC stages II and III).

The accurate evaluation of ypN status after RCT with valuable lymph node (LN) harvest is essential for postoperative risk-adapted treatment decisions.

Actual numbers of assessed LNs and validity of ypN status vary extensively depending on the methods used.

The AC method is the method of choice for accurate LN staging in locally advanced rectal cancer, especially after preoperative RCT, and is well suited for routine gastrointestinal pathology workup. (#22251939#)

References

- Optimal lymph node harvest in rectal cancer (UICC stages II and III) after preoperative 5-FU-based radiochemotherapy. Acetone compression is a new and highly efficient method. Gehoff A, Basten O, Sprenger T, Conradi LC, Bismarck C, Bandorski D, Merkelbach-Bruse S, Schneider-Stock R, Stoehr R, Wirtz RM, Kitz J, Müller A, Hartmann A, Becker H, Ghadimi BM, Liersch T, Rüschoff J. Am J Surg Pathol. 2012 Feb;36(2):202-13. PMID: #22251939#

- Impact of Tumor Response on Survival After Radiochemotherapy in Locally Advanced Rectal Carcinoma. Rullier A, Laurent C, Capdepont M, Vendrely V, Bioulac-Sage P, Rullier E. Am J Surg Pathol. 2010 Mar 4. PMID : 20216380