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oncocytic adrenocortical carcinoma

Wednesday 14 July 2010

Synopsis

- whitish tumor
- encapsulated tumor
- large polygonal tumor cells
- diffuse architecture
- abundant eosinophilic granular cytoplasm
- nuclear atypia
- atypical mitotic figures
- capsular and sinusoidal invasions

Immunochemistry

- vimentin +
- NSE + (neuron-specific enolase)
- synaptophysin +
- alpha-inhibin
- melan A
- p53

- Diffuse and strong immunopositivity with an antimitochondrial antibody proves that this tumor is truly oncocytic.

See also

- adrenocortical carcinoma

References

- Oncocytic adrenocortical carcinoma. Ohtake H, Kawamura H, Matsuzaki M, Yokoyama E, Kitajima M, Onizuka S, Yamakawa M. Ann Diagn Pathol. 2010 Jun;14(3):204-8. PMID: 20471567

- Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions. Mete O, Asa SL. Endocr Pathol. 2009 Fall;20(3):182-5.PMID: 19462261

- Adrenocortical oncocytic carcinoma with recurrent metastases: a case report and review of the literature. Argyriou P, Zisis C, Alevizopoulos N, Kefaloyannis EM, Gennatas C, Petraki CD. World J Surg Oncol. 2008 Dec 17;6:134.PMID: 19091123 [Free]