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nodal endosalpingiosis

Monday 6 September 2010

The occurrence of benign epithelial inclusions in lymph nodes is well documented and can sometimes mimic metastatic carcinoma.

Benign müllerian inclusions, such as endometriosis and endosalpingiosis, are common in pelvic and para-aortic lymph nodes, but their presence in supradiaphragmatic lymph nodes is a rare event.

Endosalpingiosis can involve axillary lymph nodes and closely simulate metastatic mammary carcinoma.

Morphologic identification of ciliated cells and "peg" cells is most helpful to recognize this benign inclusion, and positive immunoreactivity for WT1 and/or PAX8 can be used to support the diagnosis.

References

- Nodal endosalpingiosis in ovarian serous tumors of low malignant potential with lymph node involvement: a case for a precursor lesion. Djordjevic B, Clement-Kruzel S, Atkinson NE, Malpica A. Am J Surg Pathol. 2010 Oct;34(10):1442-8. PMID: 20871218

- Endosalpingiosis in axillary lymph nodes: a possible pitfall in the staging of patients with breast carcinoma. Corben AD, Nehhozina T, Garg K, Vallejo CE, Brogi E. Am J Surg Pathol. 2010 Aug;34(8):1211-6. PMID: 20631604