HPV-associated squamous cell carcinoma of the upper aerodigestive tract
Tuesday 7 September 2010
The majority of HPV-associated SCCs are oropharyngeal (base of tongue and palatine tonsils), although both sinonasal and laryngeal tumors were also associated with infection (67% and 33% of cases, respectively).
Given the better prognosis of HPV-associated SCCs of the upper aerodigestive tract, it may be prudent to report the p16 and HPV status of these tumors when they are encountered.
squamous cell carcinoma of the upper aerodigestive tract
Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract. Stelow EB, Jo VY, Stoler MH, Mills SE. Am J Surg Pathol. 2010 Jul;34(7):e15-24. PMID: 20534998 (Review)
Papillary Squamous Cell Carcinoma of the Head and Neck: Frequent Association With Human Papillomavirus Infection and Invasive Carcinoma. Jo VY, Mills SE, Stoler MH, Stelow EB. Am J Surg Pathol. 2009 Sep 9. PMID: 19745700