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uterine tumors resembling ovarian sex cord tumors

Monday 22 November 2010

Definition: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms thought to be of putative endometrial stromal origin and solely composed of sex cord elements.

UTROSCTs have a diverse immunohistochemical profile often coexpressing sex cord, epithelial, and smooth muscle markers.

The expression of smooth muscle markers in these tumors does not imply a smooth muscle origin as endometrial and sex cord stromal tumors are not infrequently positive for these markers. (#21084963#)

Positivity for sex cord markers supports a true sex cord/steroid phenotype.

Although the immunohistochemical profile of these tumors overlaps with that of endometrial stromal tumors with sex cord-like differentiation as well as ovarian sex cord stromal tumors, the origin of UTROSCT remains uncertain. (#21084963#)

References

- Diverse Phenotypic Profile of Uterine Tumors Resembling Ovarian Sex Cord Tumors: An Immunohistochemical Study of 12 Cases. de Leval L, Lim GS, Waltregny D, Oliva E. Am J Surg Pathol. 2010 Nov 16. PMID: #21084963#