HPV-associated anal lesions
Tuesday 30 November 2010
The classification of anal intraepithelial neoplasia (AIN) in mucosal biopsies is subject to considerable interobserver variability. Ki-67 and p16/CDKN2A immunostains aid detection of dysplasia in biopsy samples from the uterine cervix.
Ki-67 labeling detects anal HPV-related changes with a high degree of sensitivity and specificity, whereas increased p16/CDKN2A staining is strongly associated with high-grade squamous neoplasia. A combination of these markers may aid interpretation of anal mucosal biopsy samples. (20871219)
P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Pirog EC, Quint KD, Yantiss RK. Am J Surg Pathol. 2010 Oct;34(10):1449-55. PMID: 20871219