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teratoma models

Wednesday 19 January 2011

Differentiation of human embryonic stem cells (HESCs) can be studied in vivo through the induction of teratomas in immune-deficient mice. Cells within the teratomas differentiate into all three embryonic germ layers.

In vivo differentiation of HESCs is polyclonal and, thus, may not be cell autonomous, stressing the need for a three-dimensional growth in order to achieve complex differentiation of HESCs. (17464084)

References

- An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. Mensah A, Mulligan C, Linehan J, Ruf S, O’Doherty A, Grygalewicz B, Shipley J, Groet J, Tybulewicz V, Fisher E, Brandner S, Nizetic D. BMC Dev Biol. 2007 Nov 29;7:131. PMID: 18047653

- Clonal analysis of human embryonic stem cell differentiation into teratomas. Blum B, Benvenisty N. Stem Cells. 2007 Aug;25(8):1924-30. PMID: 17464084 (Free)