Tuesday 5 April 2011
Definition: Necroptosis is a programmed form of necrosis, or inflammatory cell death.
Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis.
Furthermore, the immunogenic nature of necroptosis favors its use in certain circumstances, such as aiding targeting of pathogens by the immune system.
Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo “cellular suicide” in a caspase-independent fashion in the presence of viral caspase inhibitors.
Cell death: A killer puts a stop on necroptosis. Wrighton KH. Nat Rev Mol Cell Biol. 2011 Mar 30. PMID: 21448226