Wednesday 21 December 2011
Limited dorsal myeloschisis (LDM) is a distinctive form of spinal dysraphism characterized by 2 constant features: a focal "closed" midline defect and a fibroneural stalk that links the skin lesion to the underlying cord.
The embryogenesis is hypothesized to be incomplete disjunction between cutaneous and neural ectoderms, thus preventing complete midline skin closure and allowing persistence of a physical link (fibroneural stalk) between the disjunction site and the dorsal neural tube.
Limited dorsal myeloschisis: a distinctive clinicopathological entity. Pang D, Zovickian J, Oviedo A, Moes GS. Neurosurgery. 2010 Dec;67(6):1555-79; PMID: 21107187