Tuesday 3 January 2012
Canonical and non-canonical autophagy
Macroautophagy has important physiological roles during development, ageing and the immune response, and its cytoprotective function is compromised in various diseases.
A set of autophagy-related (ATG) proteins is hierarchically recruited to the phagophore, the initial membrane template in the construction of the autophagosome.
Macroautophagy can also occur in the absence of some of these key autophagy proteins, through the unconventional biogenesis of canonical autophagosomes.
autophagy in cancer