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ADAR2

Sunday 20 August 2017

Pathology

- Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.

  • ADAR2 is overexpressed in EC and that the increase in expression positively correlates with the aggressiveness of the tumor.
  • Furthermore, silencing of ADAR2 in three EC cell lines resulted in a decreased proliferation rate, increased apoptosis, and reduced migration capabilities in vitro.
  • ADAR2 functions as an oncogene in endometrial carcinogenesis and could be a potential target for improving EC treatment strategies.
  • doi : 10.1038/s41598-017-09169-2

See also

- ADARs
- RNA editing