Home > E. Pathology by systems > Endocrine system > Adrenals > adrenal cortical tumors

adrenal cortical tumors

Friday 2 March 2012

adrenocortical tumors

Digital cases

- JRC:14604 : Adrenal cortical adenoma.
- JRC:14612 : Atypical adrenal cortical adenoma.
- JRC:14613 : Adrenal cortical carcinoma (with Cushing syndrome)
- JRC:18771 : Adrenal carcinoma (NOS)
- JRC:18772 : Adrenal adenoma (NOS).

Types according to grade

- adrenocortical adenoma (adrenal cortical adenoma)
- adrenocortical carcinoma (adrenal cortical carcinoma)

Types according to secretion

- non-secreting adrenocortical tumor
- androgens-secreting adrenocortical tumor
- aldosterone-secreting adrenocortical tumor
- cortisol-secreting adrenocortical tumor

Types according to age

- pediatric adrenal cortical tumors

Typing

- Weiss Score (WS) system

  • The pathologic diagnosis of adrenocortical carcinoma (ACC) still needs to be improved, because the renowned Weiss Score (WS) system has a poor reproducibility of some parameters and is difficult to apply in borderline cases and in ACC variants.

- reticulin algorithm (23774167)

  • The "reticulin algorithm" (RA) defines malignancy through an altered reticulin framework associated with 1 of the 3 following parameter: necrosis, high mitotic rate, and vascular invasion.
  • Reticulin staining is a reliable technique and an easy-to-interpret system in adrenocortical tumors. 23774167)
  • It has a high interobserver reproducibility, which supports the notion of using such a method in the proposed 2-step RA approach for ACC diagnosis. 23774167)

LOH

- 17q22-24 LOH (PRKAR1A locus) (14500362)

Gene mutations

- somatic mutations in the PRKAR1A gene (14500362)

References

- The Reticulin Algorithm for Adrenocortical Tumor Diagnosis: A Multicentric Validation Study on 245 Unpublished Cases. Duregon E, Fassina A, Volante M, Nesi G, Santi R, Gatti G, Cappellesso R, Dalino Ciaramella P, Ventura L, Gambacorta M, Dei Tos AP, Loli P, Mannelli M, Mantero F, Berruti A, Terzolo M, Papotti M. Am J Surg Pathol. 2013 Jun 14. PMID: 23774167

- Adrenocortical Tumors: Improving the Practice of the Weiss System Through Virtual Microscopy: A National Program of the French Network INCa-COMETE. Tissier F, Aubert S, Leteurtre E, Al Ghuzlan A, Patey M, Decaussin M, Doucet L, Gobet F, Hoang C, Mazerolles C, Monges G, Renaudin K, Sturm N, Trouette H, Vacher-Lavenu MC, Viallon V, Baudin E, Bertagna X, Coste J, Libe R. Am J Surg Pathol. 2012 Aug;36(8):1194-1201. PMID: 22790860