duodenal hyperplastic polyp

Benign serrated polyps are commonly found in the colorectum but have rarely been described in other parts of the gastrointestinal tract.

Hyperplastic polyps or sessile serrated polyps in the colorectum can be associated. (#21733555#) In a study, no patient met the criteria for serrated polyposis. (#21733555#)

Although probably rare and of uncertain malignant potential, duodenal hyperplastic polyp should be considered in the differential diagnosis of benign duodenal polyp.

Microscopy

The histologic appearance of the benign serrated polyps of the duodenum is similar to microvesicular hyperplastic polyp in the colorectum.

Immunochemistry

Immunostaining for mucins shows MUC6 expression in the crypt bases of all polyps, MUC5AC expression in 89%, and mucin 2 expression in 67%. (#21733555#)

Genetics

Molecular testing showed BRAF mutation (V600E) in some polyps, KRAS mutation in some polyps. (#21733555#)

References

 Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings. Rosty C, Buchanan DD, Walters RJ, Carr NJ, Bothman JW, Young JP, Brown IS. Hum Pathol. 2011 Dec;42(12):1953-9. PMID: #21733555#

 Regression of multiple duodenal hyperplastic polyps following Helicobacter pylori eradication. Ugajin T, Miyatani H, Matsumoto S, Takamatsu T, Fukunishi M, Yoshida Y, Dobashi Y. Dig Endosc. 2011 Oct;23(4):328. PMID: #21951097#